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TRADD

  • Official Full Name

    TNFRSF1A-associated via death domain

  • Overview

    Apoptosis mediated by death factors like FasL and TNF-alpha involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) c
  • Synonyms

    TRADD; TNFRSF1A-associated via death domain; tumor necrosis factor receptor type 1-associated DEATH domain protein; Hs.89862; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1 associated death domain protein; MGC11078;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRADD-3383H Recombinant Human TRADD protein, His-tagged E.coli His 1-312 aa
Human TRADD-29977TH Recombinant Human TRADD, His-tagged E.coli His
Human TRADD-826HCL Recombinant Human TRADD 293 Cell Lysate HEK293 N/A
Human TRADD-4420H Recombinant Human TRADD protein, GST-tagged E.coli GST 1-312aa
Human TRADD-6657H Recombinant Human TRADD Protein (Met61-Leu297), N-His tagged E.coli N-His Met61-Leu297
Human TRADD-3384H Recombinant Human TRADD protein, His-tagged E.coli His Met61~Leu297
Mouse Tradd-1415M Recombinant Mouse Tradd protein, His & T7-tagged E.coli His/T7 Ser21~Leu259 (Accession # Q3U0V2)
Rat Tradd-1416R Recombinant Rat Tradd protein, His & T7-tagged E.coli His/T7 Asp24~Glu261 (Accession # D3ZZC5)
Zebrafish TRADD-9147Z Recombinant Zebrafish TRADD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRADD Related Articles
  • TRADD Related Research Area

TRADD involved in several pathways and played different roles in them. We selected most pathways TRADD participated on our site, such as NF-kappa B signaling pathway, Sphingolipid signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayBLNK;CXCL12;TNFSF11;CCL13;TRIM25;CFLAR;MAP3K14;TNFAIP3;IL1R1
Sphingolipid signaling pathwayAKT1;GNAI1;PPP2R5E;ABCC1;MAPK3;S1PR4;TP53;PLD2;AKT2
ApoptosisAKT1;DIABLOB;TICAM1;CFLARA;IRF4A;BOKA;STK26;PRKAR2AA;NFKB1
RIG-I-like receptor signaling pathwayIFNA3;MAPK14A;PIN1;IL12B;DAK;NFKBIAA;NT5C3;TANK;IFNA14
TNF signaling pathwayMAPK9;CX3CL1;CREB5;MMP3;CCL2;DNM1L;PIK3R1;ATF4;MMP14
Adipocytokine signaling pathwayPCK1;SLC2A1;ADIPOQB;PRKAG3B;TNFRSF1B;RXRA;CAMKK1A;POMC;RXRGB
TuberculosisRAB5C;IFNA6;C3;CD74;HLA-DRB3;TLR9;BAX;HSPD1;FCGR2B
Hepatitis CCLDN4;OCLN;OAS3;NFKBIA;EIF2AK1;IFIT1;IFN-a;CLDN15;IFNA12
Epstein-Barr virus infectionCD44;MAP2K4;POLR3GL;MAPK8;BCL2;POLR1C;NFKBIE;PIK3R2;MAP2K6
Viral carcinogenesisGTF2B;PIK3R2;RBPJ;HDAC7A;HIST2H4;H2BFWT;HDAC1;HIST1H4A;YWHAE

TRADD has several biochemical functions, for example, binding, bridging, death domain binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRADD itself. We selected most functions TRADD had, and list some proteins which have the same functions with TRADD. You can find most of the proteins on our site.

Function Related Protein
binding, bridgingTRADD;PDCD6;GAS6
death domain bindingTRADD;DAP;DAP1B;DAPL1;RIPK1;CRADD
identical protein bindingSYT9;BNIPL;FUS;SYP;AGER;PIK3AP1;ROBO2;CALCA;CBX3
kinase bindingPARK7;SLC2A1;RASGRP3;BTG1;MOB4;BARD1;DUSP12;TRIP6;CAB39
protein bindingRTN4RL1B;TNFRSF13B;ADRM1;SDHAF2;CEP55;C9orf43;TARBP2;PLEK;JAG2
protein complex bindingRPTOR;CDK5RAP1;CDH2;SLC9A3R1;KCTD5;ATG101;ARRB2;STRN4;DRD1A
signal transducer activityMRGPRA5;TRIM13;JUPA;OPRD1A;ZDHHC13;ADRA2DA;MAS1;TMTOPS2B;SLC35B2
tumor necrosis factor receptor bindingTNF;TNFSF14;TNFSF10L4;FADD;TNFSF12;TRAF2;TRADD;TNFSF13;LTB

TRADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRADD here. Most of them are supplied by our site. Hope this information will be useful for your research of TRADD.

TNFRSF1A; TRAF2

Hu, R; Du, QM; et al. Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment. FEBS LETTERS 588:401-407(2014).
Hirsch, B; von der Wall, E; et al. RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells. LABORATORY INVESTIGATION 93:677-689(2013).
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