TRDMT1
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Official Full Name
tRNA aspartic acid methyltransferase 1
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Overview
tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
TRDMT1; tRNA aspartic acid methyltransferase 1; DNA (cytosine 5 ) methyltransferase 2 , DNMT2; tRNA (cytosine(38)-C(5))-methyltransferase; RNMT1; DNA methyltransferase-2; DNA MTase homolog HsaIIP; tRNA (cytosine-5-)-methyltransferase; DNA (cytosine-5)-met;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TRDMT1-787H | Recombinant Human TRDMT1, His-tagged | Insect Cell | His |
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| Human | TRDMT1-4051H | Recombinant Human TRDMT1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | TRDMT1-28370TH | Recombinant Human TRDMT1 | Wheat Germ | N/A | 391 amino acids |
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| Human | TRDMT1-6969H | Recombinant Human TRDMT1 , GST-tagged | Sf9 Insect Cell | GST | Full length |
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| Human | TRDMT1-15835H | Recombinant Human TRDMT1, His-tagged | E.coli | His | 1-391aa |
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| Human | TRDMT1-512H | Recombinant Human TRDMT1, GST-tagged | Insect Cell | GST |
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| Human | TRDMT1-5583H | Recombinant Human TRNA Aspartic Acid Methyltransferase 1, His-tagged | E.coli | His |
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| Human | TRDMT1-309H | Recombinant Human TRDMT1 Protein, GST-tagged | Insect Cell | GST |
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| Human | TRDMT1-695HCL | Recombinant Human TRDMT1 cell lysate | Insect Cell | N/A |
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| Human | TRDMT1-529HF | Recombinant Full Length Human TRDMT1 Protein | In Vitro Cell Free System | 391 amino acids |
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| Human | TRDMT1-4755HF | Recombinant Full Length Human TRDMT1 Protein, GST-tagged | In Vitro Cell Free System | GST | 391 amino acids |
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| Mouse | TRDMT1-17316M | Recombinant Mouse TRDMT1 Protein | Mammalian Cell | His |
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| Mouse | TRDMT1-9575M-B | Recombinant Mouse TRDMT1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | TRDMT1-9575M | Recombinant Mouse TRDMT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | TRDMT1-6265R | Recombinant Rat TRDMT1 Protein | Mammalian Cell | His |
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| Rat | TRDMT1-5922R | Recombinant Rat TRDMT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | TRDMT1-5922R-B | Recombinant Rat TRDMT1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | TRDMT1-2653Z | Recombinant Zebrafish TRDMT1 | Mammalian Cell | His |
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| Chicken | TRDMT1-2201C | Recombinant Chicken TRDMT1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
TRDMT1 involved in several pathways and played different roles in them. We selected most pathways TRDMT1 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRDMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | NR2C2;NR5A1A;ZNF562;ANP32A;POLR3G;TYW3;MYBL1;NR1I3;ZNF615 |
| tRNA modification in the nucleus and cytosol | PUS7;MANEA;PUS1;TRMT5;TYW5;LAGE3;METTL1;TYW1;TRMT6 |
| tRNA processing | ADAT2;METTL1;TRMT1;OSGEP;CCDC76;C22orf28;TYW5;KIAA1456;TRMT6 |
TRDMT1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, RNA binding, tRNA methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRDMT1 itself. We selected most functions TRDMT1 had, and list some proteins which have the same functions with TRDMT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA (cytosine-5-)-methyltransferase activity | TRDMT1;DNMT1;DNMT3B;DNMT3A |
| RNA binding | SF1;CRNKL1;NUFIP1;PRPF40B;PABPN1;RPF1;DKC1;HNRNPA1;C1D |
| tRNA methyltransferase activity | PRDM13;CCDC76;RNMTL1A;LCMT2;METTL21A;PRDM11;FAM86;METTL7B;TRDMT1 |
TRDMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRDMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRDMT1.
q65zq1_human; kv203_human; SNRPA1; EPPK1; SNRPD3; EEF1A1; GBE1; UNC119; SETDB1; STX1A; RBM48; RIF1; NFRKB; COPS6; UTP14A; DDX24; TBC1D2B
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