TREM1
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Official Full Name
Triggering receptor expressed on myeloid cells 1
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Overview
TREM-1 stimulates neutrophil and monocyte-mediated inflammatory responses. It triggers release of pro- inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. It interacts with TYROBP/DAP12. TREM-1 is highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. It is also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. It is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. TREM-1 is up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS). -
Synonyms
CD354; TREM-1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Cattle
- Human
- Mouse
- Pig
- Rhesus monkey
- Rhesus Monkey
- CHO
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- Mouse
- APC
- C
- His
- hFc
- hIgG1
- hIgG4
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- TREM1 Related Research Area
TREM1 involved in several pathways and played different roles in them. We selected most pathways TREM1 participated on our site, such as Adaptive Immune System, Cell surface interactions at the vascular wall, DAP12 interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | AMICA1;AP1S3A;GM11711;KLHL21;PJA2;UBE2F;EGFR;SIGLEC8;RNF123 |
| Cell surface interactions at the vascular wall | SLC7A6;CD177;PPIA;CEACAM1;F11R.2;GRB14;FCER1GL;JAM2B;CD84 |
| DAP12 interactions | CSF2RB;KIR3DS1;DUSP1;DUSP7;DUSP9;DAB2IPB;FRS3;SPTBN1;MOV10 |
| Hemostasis | CABLES1;CFHL2;BSG;STXBP3A;TAE1;GATA1A;MAFGB;LRRC16A;RACGAP1 |
| Immune System | BTR16;LAIR1;TREML4;KLHL20;HUWE1;DYNC1I2;SPSB4;LILRA2;MAP3K8 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CLEC2H;CD200R1;CD300LB;RAET1E;LILRB1;LILRA3;HCST;CD160;LILRB5 |
| Innate Immune System | PLD4;DEFB106A;Txn1;LRRFIP1;BAIAP2;BTR06;DEFB129;CLEC6A;ABI1B |
TREM1 has several biochemical functions, for example, receptor activity, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREM1 itself. We selected most functions TREM1 had, and list some proteins which have the same functions with TREM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | VMN1R50;MED12;IGF2R;CRTAM;NLGN3B;GFRA4A;CD7;TNFRSF9;MED1 |
| scaffold protein binding | ATP2B4;KCNQ1;NLGN3;SHANK1;NLGN1;NOS3;CACNA1H;SHANK3;SRC |
TREM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREM1.
- Q&As
- Reviews
Q&As (6)
Ask a questionTREM1 protein can enhance inflammatory response during infection, but its specific relationship with antibacterial effect still needs further study.
High expression of the TREM1 protein in lung disease can trigger an excessive inflammatory response, and controlling its activity may help reduce the symptoms and inflammatory damage of lung disease.
When bacterial infection occurs, the expression of the TREM1 protein increases, which enhances the inflammatory response, which helps clear the infection and regulate the inflammatory process.
TREM1 protein is involved in immune response processes such as macrophage activation, release of inflammatory mediators, and recruitment and regulation of immune cells.
The study of TREM1 protein helps to understand the regulatory mechanism of inflammatory response and provide new targets and strategies for the treatment of inflammatory diseases.
High expression of the TREM1 protein is associated with the development and prognosis of certain diseases and can therefore serve as a biomarker for predicting and monitoring disease progression.
Customer Reviews (3)
Write a reviewThe exceptional stability of TREM1 makes it an invaluable tool for a wide range of applications.
Manufacturer's commitment to environmental sustainability is evident in its production processes, using green and renewable resources.
TREM1 has a short half-life, making it more effective and less likely to cause side effects compared to other similar proteins.
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