TRIB2
-
Official Full Name
tribbles homolog 2
-
Overview
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
TRIB2; tribbles homolog 2 (Drosophila); tribbles homolog 2; GS3955; TRB2; C5FW; FLJ57420;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Human
- Human Cells
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- TRIB2 Related Articles
TRIB2 involved in several pathways and played different roles in them. We selected most pathways TRIB2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
TRIB2 has several biochemical functions, for example, mitogen-activated protein kinase kinase binding, NOT nucleotide binding, NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIB2 itself. We selected most functions TRIB2 had, and list some proteins which have the same functions with TRIB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase kinase binding | ARRB1;ACE;TRIB1;BRAF;MAPK8IP3;TRIB2;TAOK2;RAF1;MAP3K11 |
| NOT nucleotide binding | PXK;TRIB2 |
| NOT protein kinase activity | HSPB8;TRIB1;PXK;TRIB2;STRADB;STRADA;MLKL |
| protein kinase inhibitor activity | DNAJC3;SOCS3A;CHP1;DUSP19;SOCS3B;NPM1;NCK1;SOCS3;PRKRIP1 |
| transcription factor binding | HDAC11;NR0B2;HAND1;CHCHD2;DIP2BA;HDAC2;STK4;NCOR2;ID1 |
| ubiquitin protein ligase binding | LYN;SNX9;RBX1;NEDD8;UBE2R2;CBS;HDAC6;BAG5;TRIB3 |
| ubiquitin-protein transferase regulator activity | TRIB2;TRIB1;TRIB3 |
TRIB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIB2.
LRRK2; BTRC; PRMT6; SLAMF7; UBQLN4; CARD16; TCF4; CTNNB1; RFWD2; SMURF1
- Q&As
- Reviews
Q&As (7)
Ask a questionTRIB2 can modulate apoptosis either by promoting or inhibiting apoptotic signaling pathways, depending on the cellular context.
TRIB2 expression and activity are regulated by factors such as hormonal changes, stress, and cellular metabolic status.
Mutations in TRIB2 may alter its functional role, affecting interactions with other proteins and potentially leading to aberrant cellular processes.
TRIB2 expression can be elevated in certain cancers, influencing tumor progression and prognosis.
TRIB2 may contribute to drug resistance in cancer by altering cell survival pathways and interacting with drug metabolism mechanisms.
TRIB2 plays a role in the inflammatory response, possibly by modulating signaling pathways involved in immune cell regulation.
TRIB2 is involved in various signaling pathways, including those related to cell survival and proliferation, such as the MAPK and AKT pathways.
Customer Reviews (3)
Write a reviewValuable insights for our protein experiments.
Timely delivery, aids our research progress.
Highly skilled team, excellent analytical services.
Ask a Question for All TRIB2 Products
Required fields are marked with *
My Review for All TRIB2 Products
Required fields are marked with *
