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TRIM27

Official Full Name

Tripartite Motif Containing 27
Overview

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a;RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It;interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in;the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the;RET gene product has been shown to result in production of the ret transforming protein.
Synonyms

TRIM27; tripartite motif containing 27; RFP; RNF76; zinc finger protein RFP; OTTHUMP00000029314; OTTHUMP00000107284; ret finger protein; RING finger protein 76; RFP transforming protein; tripartite motif-containing 27; tripartite motif protein TRIM27; tripartite motif-containing protein 27;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TRIM27-687H	Recombinant Human TRIM27 Protein, His-tagged	E.coli	His	Inquiry
Human	TRIM27-786HCL	Recombinant Human TRIM27 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	TRIM27-17352M	Recombinant Mouse TRIM27 Protein	Mammalian Cell	His	Inquiry
Mouse	TRIM27-9599M-B	Recombinant Mouse TRIM27 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	TRIM27-9599M	Recombinant Mouse TRIM27 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	TRIM27-4959R	Recombinant Rhesus monkey TRIM27 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	TRIM27-4773R	Recombinant Rhesus Macaque TRIM27 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	TRIM27-4773R-B	Recombinant Rhesus Macaque TRIM27 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	TRIM27-2375C	Recombinant Chicken TRIM27	Mammalian Cell	His	Inquiry
Chicken	TRIM27-3719C	Recombinant Chicken TRIM27	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRIM27 Related Articles

TRIM27 involved in several pathways and played different roles in them. We selected most pathways TRIM27 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TRIM27 has several biochemical functions, for example, DNA binding, ligase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM27 itself. We selected most functions TRIM27 had, and list some proteins which have the same functions with TRIM27. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	KHDRBS1;STAT5B;IRX5;MGMT;HES7;ZFP37;H2BFWT;NKRF;JRK
ligase activity	PPIL2;MGRN1;ZSWIM2;PARK2;RNF126;E4F1;STUB1;PCXA;UBE2L3A
metal ion binding	PRLR;ITGA10;NT5C;PAPD7;ZNF254;KLF15;ATP2A2A;NUBPL;ITGB7
nucleic acid binding	CHAMP1;EAR1;RBM33;PABPN1;RBM39A;PDCD11;SALL3;ZNFL2A;CPSF1
protein binding	PEX2;PRKAB1;PRC1;BCL11A;PACSIN3;DYRK2;LILRB3;KCNE4;FAT4
transmembrane receptor protein tyrosine kinase activity	KITB;EPHB4A;TRIM27;RYK;ROR2;ERBB4A;NPTNB;FLT3;TYRO3
ubiquitin-protein transferase activity	RNF31;TOPORS;ZER1;MIB1;FBXO11;UBE2W;RLIM;RNF168;FBXO25
zinc ion binding	MME;CBL;MMP30;ZDHHC3A;ABLIM1;NUP153;MKRN1;FHL5;DBF4B

TRIM27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM27 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM27.

NEDD9; JOSD1; PPP1R18; ZNF417; TUFT1

Oh, Y; Chung, KC; et al. UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9102-9111(2013).

Horio, M; Kato, T; et al. Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer. CANCER MEDICINE 1:218-229(2012).