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TRIM28

  • Official Full Name

    tripartite motif containing 28

  • Overview

    The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
  • Synonyms

    TRIM28; tripartite motif containing 28; transcription intermediary factor 1-beta; KAP1; RNF96; TF1B; TIF1B; KAP-1; KRIP-1; TIF1-beta; RING finger protein 96; KRAB-associated protein 1; nuclear corepressor KAP-1; KRAB-interacting protein 1; E3 SUMO-protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRIM28-225H Recombinant Human TRIM28 Protein, GST-tagged E.coli GST 619-811
Human TRIM28-82H Recombinant Human TRIM28, His&FLAG-tagged E.coli His/Flag
Human TRIM28-2325H Recombinant Human TRIM28, His-tagged E.coli His 366-802aa
Human TRIM28-226H Recombinant Human TRIM28 Protein, His-tagged E.coli His 619-811
Human TRIM28-1825HCL Recombinant Human TRIM28 cell lysate N/A
Human TRIM28-5221H Recombinant Human TRIM28 protein, GST-tagged E.coli GST 22-291aa
Human TRIM28-2255H-B Recombinant Human TRIM28 Protein Pre-coupled Magnetic Beads HEK293
Human TRIM28-053H Recombinant Human TRIM28 Mutant (K779R) Protein, Myc/DDK-tagged HEK293 Myc/DDK
Human TRIM28-2658H Recombinant Human TRIM28 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TRIM28-218HFL Recombinant Full Length Human TRIM28 Protein, C-Flag-tagged Mammalian cells Flag
Human TRIM28-3631H Recombinant Human TRIM28 protein, GST-tagged E.coli GST 484-835 aa
Human TRIM28-2255H Recombinant Human TRIM28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Trim28-1697M Recombinant Mouse Trim28 protein, His & T7-tagged E.coli His/T7 Pro504~Ala820 (Accession # Q62318)
Mouse Trim28-6649M Recombinant Mouse Trim28 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat TRIM28-6275R Recombinant Rat TRIM28 Protein Mammalian Cell His
Rat TRIM28-5932R Recombinant Rat TRIM28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRIM28-5932R-B Recombinant Rat TRIM28 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRIM28 Related Articles
  • TRIM28 Related Research Area

TRIM28 involved in several pathways and played different roles in them. We selected most pathways TRIM28 participated on our site, such as C-MYB transcription factor network, Corticotropin-releasing hormone, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkMYB;ADA;TRIM28;MYF6;ADORA2B;CEBPA;TOM1;CBX4;CEBPB
Corticotropin-releasing hormoneJUND;PARP1;CRHR1;ECE1;CYP21A2;CYP11A1;TBX19;CRHR2;KRT1
E2F transcription factor networkMYBL2;PRMT5;HBP1;DHFR;CBX5;CES3;E2F6;SMARCA2;UXT
Gene ExpressionZNF426;FAM98B;PTBP1;MYBL1;C22orf28;TEAD3B;NR2F6;ZNF75A;NR2F1
Generic Transcription PathwayMED10;TEAD3B;ZNF227;NR2E3;ZNF573;ZNF718;SKI;NR2C2AP;NR5A1
p53 pathwayHUWE1;FBXO11;SMYD2;NEDD8;DYRK2;TRIM28;E4F1;TTC5;CSE1L

TRIM28 has several biochemical functions, for example, DNA binding, Krueppel-associated box domain binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM28 itself. We selected most functions TRIM28 had, and list some proteins which have the same functions with TRIM28. You can find most of the proteins on our site.

Function Related Protein
DNA bindingDRL;LHX6;PAPD7;FOXO3B;ZNF653;SIM1;AHRRB;ZNF559;FOXJ1
Krueppel-associated box domain binding
RNA polymerase II transcription coactivator activityPOU3F1;SOX12;POU1F1;CREBBP;SMARCA4;PITX2;CITED2;ANKRD1;SOX11
chromo shadow domain bindingCHAF1A;ATRX;SP100;TRIM28;NIPBL;LBR
ligase activityLTN1;RNF220;RNF169;MYLIP;HERC4;HERC6;ZNRF2;TRAIP;FPGS
poly(A) RNA bindingRBM15;RPS8;ZC3H10;PPIL4;PDIA4;ZCRB1;DDX18;HIST1H4C;IGF2BP3
protein bindingGPR37;C10orf96;C1orf111;DAPK3;TH;FEM1B;SEC22C;ZNF263;PPP2R5A
protein kinase activityMAP3K1;GM711;RBM4.3;Fert2;CDKL5;OXSR1B;PRKCDA;CLK4B;GUCY2F
contributes_to sequence-specific DNA bindingFIGLA;NEUROD1;HDAC4;SMAD4;HNRNPAB;TCF3;HIF1A;PPARG;TRIM28
transcription corepressor activityMXI1;HIF3A;PPP1R13L;C1QBP;SNW1;NR1H4;YAP1;CRYM;ZFPM1
contributes_to transcription factor activity, sequence-specific DNA bindingSOX1B;TAF10;SMAD3;HNRNPAB;RXRA;TAF7;SMAD4;GATA4;SMAD2
ubiquitin protein ligase bindingRIPK1;FZD5;CBS;LYN;CDC34;HSPA9;PTPN22;CUL1A;ACTG1
ubiquitin-protein transferase activityLTN1;SMURF2;TRAF4;MARCH5L;RNF213;RNF135;FBXO2;RAG1;UBE2T
zinc ion bindingZCRB1;TRAF5;CSRP1;UBR7;ZFAND5;TRIM3;RNF149;CIZ1;RNF26

TRIM28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM28 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM28.

MAGEC2; CBX5

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Lee, M; Dworkin, AM; et al. Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation. MOLECULAR CANCER RESEARCH 12:1818-1828(2014).
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