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TRIM8

  • Official Full Name

    tripartite motif containing 8

  • Overview

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
  • Synonyms

    TRIM8; tripartite motif containing 8; ring finger protein 27 , RNF27, tripartite motif containing 8; probable E3 ubiquitin-protein ligase TRIM8; GERP; glioblastoma expressed ring finger protein; AA408830; BB006755; Lioblastoma expressed ring finger protein; Ring finger protein 27; RNF27; RP11-47A8.4; Tripartite motif protein TRIM8; tripartite motif-containing 8; tripartite motif-containing protein 8; glioblastoma-expressed RING finger protein;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRIM8-1837HCL Recombinant Human TRIM8 cell lysate N/A
Human TRIM8-2648H Recombinant Human TRIM8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TRIM8-1851H Recombinant Human TRIM8 protein, GST-tagged E.coli GST 180-351 aa
Human TRIM8-594H Recombinant Human TRIM8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse TRIM8-17400M Recombinant Mouse TRIM8 Protein Mammalian Cell His
Mouse TRIM8-9625M-B Recombinant Mouse TRIM8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Trim8-6664M Recombinant Mouse Trim8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TRIM8-9625M Recombinant Mouse TRIM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Trim8-2139R Recombinant Rat Trim8 Protein, His-tagged E.coli N-His Ile74-Ser319
Rhesus Macaque TRIM8-4975R Recombinant Rhesus monkey TRIM8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TRIM8-4789R Recombinant Rhesus Macaque TRIM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TRIM8-4789R-B Recombinant Rhesus Macaque TRIM8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TRIM8-4018Z Recombinant Zebrafish TRIM8 Mammalian Cell His
Chicken TRIM8-2893C Recombinant Chicken TRIM8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRIM8 Related Articles

TRIM8 involved in several pathways and played different roles in them. We selected most pathways TRIM8 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemGBP2;TRIM8;SPRED3;GBP4;FCGR1B;NUPL2;HLA-DQB2;TRIM68;SPTA1
Immune SystemCD200R2;RCA2.1;TRIM2;ASB9;NOD1;CD200R1;ERAP1;CD96;MYO1C
Interferon SignalingIFIT11;GBP2;USP18;IFI27;TRIM45;HLA-DQB2;TRIM10;TRIM5;TRIM46
Interferon gamma signalingOASL;TRIM2;GBP6;IRF6;TRIM46;TRIM3;TRIM10;TRIM31;GBP1

TRIM8 has several biochemical functions, for example, identical protein binding, ligase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM8 itself. We selected most functions TRIM8 had, and list some proteins which have the same functions with TRIM8. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingCLDN14;VEGFA;C1QL2;ZBTB16;DNM1L;TPCN1;ENTPD2;PRNP;RUNX1T1
ligase activityFANCL;MDM2;TRAIP;TRIM33;FPGS;ARIH1;TRIM31;UBE2L3B;RNF138
protein homodimerization activityRELA;GCA;MSH2;IKBKB;GLIPR2;CECR1;EIF2AK3;BLOC1S6;CORO1A
zinc ion bindingRNF151;TRAF1;RORC;MUL1A;CXXC5;ADAM2;RNF135;RNF170;CA5A

TRIM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM8.

TRAF5; UBE2L6; TRIM24; RNF113A; TRIM27; TRIM21; CBL; UBE2D1; CCNH; UBE2D3; UBE2D2; XIAP; MKRN3; UBE2V1; TRIM25; recN; RNF111

Caratozzolo, MF; Valletti, A; et al. TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma. ONCOTARGET 5:7446-7457(2014).
Engstrom, KS; Hossain, MB; et al. Efficient Arsenic Metabolism - The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT. PLOS ONE 8:-(2013).
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