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TRIOBP

Official Full Name

TRIO and F-actin binding protein
Overview

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
Synonyms

TRIOBP; TRIO and F-actin binding protein; DFNB28; TRIO and F-actin-binding protein; HRIHFB2122; KIAA1662; Tara; protein Tara; tara-like protein; trio-associated repeat on actin; dJ37E16.4; FLJ39315;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRIOBP-3419H	Recombinant Human TRIOBP, His-tagged	E.coli	His	C-term-375aa	$319 / 25ug
Human	TRIOBP-2638H	Recombinant Human TRIOBP Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	Triobp-460M	Recombinant Mouse Triobp Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TRIOBP involved in several pathways and played different roles in them. We selected most pathways TRIOBP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIOBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TRIOBP has several biochemical functions, for example, GTP-Rho binding, actin filament binding, myosin II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIOBP itself. We selected most functions TRIOBP had, and list some proteins which have the same functions with TRIOBP. You can find most of the proteins on our site.

Function	Related Protein
GTP-Rho binding	STXBP6L;ROCK1;PKN1;CDC42EP4;RTKN2B;ROCK2B;CDC42EP5;ROCK2A;WHAMM
actin filament binding	FSCN1A;CORO2A;GAS7;VIL1;JUB;FLNC;ESPN;TAGLN3B;WIPF1
myosin II binding	TRIOBP;GSN;GCSAM;GCET2
ubiquitin protein ligase binding	MAGEA2;PIAS1;AMBRA1;SPOP;TXNIP;RBX1;NFKBIA;ASB4;UBE2V2

TRIOBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIOBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIOBP.

Plk1; POLR1C; VIM; GTF2H1; dppD; hemA; q9wmx2-pro_0000037551; IKBKG