TRMT12
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Official Full Name
tRNA methyltransferase 12 homolog (S. cerevisiae)
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Overview
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006). -
Synonyms
TRMT12; tRNA methyltransferase 12 homolog (S. cerevisiae); tRNA methyltranferase 12 homolog (S. cerevisiae); tRNA wybutosine-synthesizing protein 2 homolog; FLJ20772; Trm12; tRNA yW synthesizing protein 2; TYW2; Radical S-adenosyl methionine and flavodoxin domain-containing protein 2; TRM 12; TRMT 12; tRNA methyltransferase 12; tRNA-yW-synthesizing protein 2; TYW2_HUMAN; tRNA-yW synthesizing protein 2; tRNA methyltranferase 12 homolog; homolog of yeast tRNA methyltransferase; alpha-amino-alpha-carboxypropyl transferase TYW2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TRMT12-755HCL | Recombinant Human TRMT12 293 Cell Lysate | HEK293 | N/A |
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| Human | TRMT12-2806H | Recombinant Human TRMT12 Protein, His-tagged | E.coli | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
TRMT12 involved in several pathways and played different roles in them. We selected most pathways TRMT12 participated on our site, such as Gene Expression, Synthesis of wybutosine at G37 of tRNA(Phe), tRNA modification in the nucleus and cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRMT12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | MED23;ZNF213;SEC61B;NR1D2B;HNRPL;ZFP2;MYBL1;ZNF264;NRBF2B |
| Synthesis of wybutosine at G37 of tRNA(Phe) | TYW3;TRMT12;LCMT2;TYW1;TRMT5;TYW5 |
| tRNA modification in the nucleus and cytosol | LCMT2;LBH;QTRT1;TRMT12;PUS7;WDR4;TYW5;ADAT3;TRMT5 |
| tRNA processing | TSEN34;C14orf166;ZBTB8OS;TRMT44;TRMT6;CCDC76;POP4;TRMT1;FAM98B |
TRMT12 has several biochemical functions, for example, protein binding, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRMT12 itself. We selected most functions TRMT12 had, and list some proteins which have the same functions with TRMT12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAC1;RAP1GDS1;CORO2B;TICAM2;EIF1AY;USP37;GTF2H4;GNAI2;SMAGP |
| transferase activity | PTDSS1A;DNMT3;PRKCDA;UGT5C3;SETDB1B;GGCTB;GSTM7;PRKACAA;ELOVL1B |
TRMT12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRMT12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRMT12.
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