Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

TRPC6

  • Official Full Name

    transient receptor potential cation channel, subfamily C, member 6

  • Overview

    The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
  • Synonyms

    TRPC6; transient receptor potential cation channel, subfamily C, member 6; TRP6; FSGS2; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPC6-741HCL Recombinant Human TRPC6 293 Cell Lysate HEK293 N/A
Human TRPC6-347H Recombinant Human TRPC6 Protein, His-tagged E.coli His Met1~Leu192
Human TRPC6-1162HFL Recombinant Human TRPC6 protein, His&Flag-tagged HEK293 His&Flag 1-931 aa
Bos taurus (Bovine) RFL28781BF Recombinant Full Length Bovine Short Transient Receptor Potential Channel 6(Trpc6) Protein, His-Tagged E.coli expression system His Full Length (1-89)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPC6 Related Articles

TRPC6 involved in several pathways and played different roles in them. We selected most pathways TRPC6 participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayCREB3L3;PIK3CD;MAPK1;MYLK4;ATF4;VASP;PPP1R12A;CALML3;GNAI1

TRPC6 has several biochemical functions, for example, inositol 1,4,5 trisphosphate binding, protein binding, store-operated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC6 itself. We selected most functions TRPC6 had, and list some proteins which have the same functions with TRPC6. You can find most of the proteins on our site.

Function Related Protein
inositol 1,4,5 trisphosphate bindingTRPC5A;TRPC4;TRPC3;RPH3A;TRPC5;TRPC6A;AKR1C1;CYTH2;TRPC1
protein bindingPGF;C1QA;FMO4;CD274;AKAP9;SP100;TRAP1;TRIM67;CTSK
store-operated calcium channel activityTRPC3;TRPC6;ORAI2;ZP3;TRPC1;TRPC2B;TRPC5;ORAI3;TRPC2

TRPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC6.

MX1; ITPR3

Zhang, JC; Mao, XB; et al. IL-17A CONTRIBUTES TO BRAIN ISCHEMIA REPERFUSION INJURY THROUGH CALPAIN-TRPC6 PATHWAY IN MICE. NEUROSCIENCE 274:419-428(2014).
Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All TRPC6 Products

Required fields are marked with *

My Review for All TRPC6 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends