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TRPC3

  • Official Full Name

    transient receptor potential cation channel, subfamily C, member 3

  • Overview

    The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    TRPC3; transient receptor potential cation channel, subfamily C, member 3; TRP3; short transient receptor potential channel 3; hTrp-3; transient receptor protein 3; transient receptor potential cation channel subfamily C member 3 variant c;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • Flag
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPC3-745HCL Recombinant Human TRPC3 293 Cell Lysate HEK293 N/A
Human TRPC3-1159HFL Recombinant Human TRPC3 protein, His&Flag-tagged HEK293 His&Flag 1-921 aa
Human TRPC3-6113H Recombinant Human TRPC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Trpc3-6676M Recombinant Mouse Trpc3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TRPC3-8414Z Recombinant Zebrafish TRPC3 Mammalian Cell His
Chicken TRPC3-4609C Recombinant Chicken TRPC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPC3 Related Articles

TRPC3 involved in several pathways and played different roles in them. We selected most pathways TRPC3 participated on our site, such as Axon guidance, Developmental Biology, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEPHB2;FRS2;FRS2B;JAK2;CDK5R1B;PLXND1;DPYSL3;EFNB3B;SEMA3E
Developmental BiologyDLG3;MED6;FGF20A;DCC;MED31;SCN3B;EZRA;FOXD3;ARPC1A
Effects of PIP2 hydrolysisABHD6B;DGKQ;TRPC3;TAE1;DGKB;TRPC6A;RASGRP2;PRKCHB;MGLL
Elevation of cytosolic Ca2+ levelsTRPC7;TRPC3;TRPC6A
G alpha (q) signalling eventsFPR-RS6;LPAR2B;ABHD12;ARHGEF25;GPR17;GPR4;NPSR1;EDNRA;PRKCHB
GPCR downstream signalingUTS2D;OXGR1A.1;GHRH;QRFPR;NPS;ABHD12;PRKCHB;TAAR1;QRFP
Gastrin-CREB signalling pathway via PKC and MAPKEDN3;NTS;GRP;NPSR1;ANXA1C;GPRC6A;ABHD6B;GPR65;NMUR1
HemostasisPHF21A;GRB7;MAFGB;RHOB;PDE10A;ANXA2;DGKG;NFE2;CD9A

TRPC3 has several biochemical functions, for example, calcium channel activity, inositol 1,4,5 trisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC3 itself. We selected most functions TRPC3 had, and list some proteins which have the same functions with TRPC3. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityPKD2L2;ITPR3;TRPV5;TRPM8;CACNG7A;ORAI1B;SLC24A4;RYR2;RYR1B
inositol 1,4,5 trisphosphate bindingTRPC1;TRPC7;RPH3A;TRPC6A;TRPC6;TRPC5A;ITPR3;TRPC3;AKR1C1
protein bindingTOLLIP;MT2A;PTRH2;P4HA1;TPX2;KLHL35;ACTL6A;PRAM1;FOS
store-operated calcium channel activityZP3;ORAI2;TRPC6A;TRPC2;ORAI3;ORAI1;TRPC1;STIM2;TRPC6

TRPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC3.

ITPR3; MX1; Plcg1

Xie, YF; Zhou, FM; et al. TRPC3 channel mediates excitation of striatal cholinergic interneurons. NEUROLOGICAL SCIENCES 35:1757-1761(2014).
Zhou, FW; Roper, SN; et al. TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia. JOURNAL OF NEUROPHYSIOLOGY 111:1227-1237(2014).
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