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TRPM5

Official Full Name

transient receptor potential cation channel, subfamily M, member 5
Overview

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele.
Synonyms

TRPM5; transient receptor potential cation channel, subfamily M, member 5; transient receptor potential cation channel subfamily M member 5; LTRPC5; MTR1; 9430099A16Rik; Long transient receptor potential channel 5; MLSN1 and TRP related gene 1; MLSN1 and TRP related gene 1 protein; MLSN1 and TRP-related; Novel protein similar to vertebrate transient receptor potential cation channel, subfamily M, member 5; TRPM5 transient receptor potential cation channel, subfamily M, member 5; LTrpC-5; MLSN1- and TRP-related gene 1 protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Flag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRPM5-3435H	Recombinant Human TRPM5, GST-tagged	E.coli	GST	1-350aa	$319 / 25ug
Human	TRPM5-1167HFL	Recombinant Human TRPM5 protein, His&Flag-tagged	HEK293	His&Flag	1-1165 aa	Inquiry
Mouse	TRPM5-17456M	Recombinant Mouse TRPM5 Protein	Mammalian Cell	His		Inquiry
Mouse	TRPM5-9657M	Recombinant Mouse TRPM5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TRPM5-9657M-B	Recombinant Mouse TRPM5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TRPM5-6813Z	Recombinant Zebrafish TRPM5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRPM5 Related Articles

TRPM5 involved in several pathways and played different roles in them. We selected most pathways TRPM5 participated on our site, such as Taste transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Taste transduction	TAS2R106;TAS2R126;TAS2R20;TAS2R113;TAS2R139;TAS2R103;TAS1R2;TAS1R3;GNG13

TRPM5 has several biochemical functions, for example, calcium activated cation channel activity, ion channel activity, potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM5 itself. We selected most functions TRPM5 had, and list some proteins which have the same functions with TRPM5. You can find most of the proteins on our site.

Function	Related Protein
calcium activated cation channel activity	TRPM4A;TRPM5;CATSPER1;TRPM4;PKD2L1;ANO10;TMEM63C;CATSPER2;CALHM1
ion channel activity	KCNH1B;KCNC3B;GRIA3B;TRPC6A;KCNH2A;TPC3;KCNC1A;GRIN2BB;RYR1B
potassium channel activity	KCNC2;KCNC4;DDX1;KCNK13A;KCNA2B;KCNB2;KCNK13B;AQP1;KCNH6A
sodium channel activity	ACCN5;SCNN1G;SCN4AB;ASIC1B;ASIC3;TRPM2;ACCN4;SCN8AB;SCN12AA
voltage-gated ion channel activity	KCNJ1A.5;KCNC1B;KCNS3A;SCN11A;TPC3;CACNA1SB;KCNC1A;KCNJ1B;CACNA2D3

TRPM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM5.

Panneck, AR; Rafiq, A; et al. Cholinergic epithelial cell with chemosensory traits in murine thymic medulla. CELL AND TISSUE RESEARCH 358:737-748(2014).

Eberle, JAM; Richter, P; et al. Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication. FRONTIERS IN PHYSIOLOGY 4:-(2013).