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TRPS1

  • Official Full Name

    trichorhinophalangeal syndrome I

  • Overview

    This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.
  • Synonyms

    TRPS1; trichorhinophalangeal syndrome I; zinc finger transcription factor Trps1; LGCR; zinc finger protein GC79; tricho-rhino-phalangeal syndrome type I protein; GC79; MGC134928;

  • Recombinant Proteins
  • Human
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293T
  • Mammalian Cell
  • GST
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPS1-3437H Recombinant Human TRPS1, His-tagged E.coli His 22-371aa
Human TRPS1-301463H Recombinant Human TRPS1 protein, GST-tagged E.coli GST Ser1158-Glu1281
Human TRPS1-3440H Recombinant Human TRPS1 protein, GST-tagged E. coli 1158-1281 aa
Human TRPS1-839HCL Recombinant Human TRPS1 lysate, MYC/DDK-tagged HEK293T
Human TRPS1-3438H Recombinant Human TRPS1 protein, His-tagged E. coli 9-358 aa
Human TRPS1-3193H Recombinant Human TRPS1 protein, His-tagged E.coli His 1158-1281 aa
Human TRPS1-3439H Recombinant Human TRPS1 protein, His-tagged E. coli 1158-1281 aa
Zebrafish TRPS1-7752Z Recombinant Zebrafish TRPS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPS1 Related Articles
  • TRPS1 Related Research Area

TRPS1 involved in several pathways and played different roles in them. We selected most pathways TRPS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

TRPS1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPS1 itself. We selected most functions TRPS1 had, and list some proteins which have the same functions with TRPS1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingAEBP1;RXRG;ZFP551;STAT4;CREB3L4;NR1D1;ZNF561;IKZF5;SUV39H1
RNA polymerase II transcription factor bindingMIXL1;MTDH;Ar;DHX9;SFPI1;ZFPM1;GATA2;GATA1;MEF2A
chromatin bindingCDK9;CHAF1A;ATAD2B;NCOA1;HINFP;SP140L;GATA2B;MECP2;SMARCE1
protein bindingZHX1;CALCRL;COMT;PSMG1;ETF1;PREP;POLDIP3;SMR3B;CRYBA2
transcription factor activity, sequence-specific DNA bindingMYCL1;TP63;LHX8A;PDX1;TULP4;ZNF92;TCEAL1;NR4A2A;SOX1
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingATF3;GATA2;HIF1A;TRPS1;ZGLP1;TRP53;SOX17;GABPA;GATA2B
zinc ion bindingCA9;ADAM1B;NR4A2A;OTUD7B;LIG3;ATRX;FBXO11;ESRRA;RNF34B

TRPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPS1.

ORF; RNF4; Dynll1; maP3; clpB; CDK2AP1; SEC16A; Tuba3a; MAPK3; DYNLL1; CDK18; HDAC1; MCM6; Mta1; Kctd5; CEP170P1

Hufeland, M; Rahner, N; et al. Trichorhinophalangeal Syndrome Type I: A Novel Mutation and Perthes-like Changes of the Hip in a Family With 4 Cases Over 3 Generations. JOURNAL OF PEDIATRIC ORTHOPAEDICS 35:E1-E5(2015).
Pereda, A; Azriel, S; et al. Pseudohypoparathyroidism vs. tricho-rhinophalangeal syndrome: patient reclassification. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 27:1089-1094(2014).
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