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TSC2

Official Full Name

tuberous sclerosis 2
Overview

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms

TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TSC2-31631TH	Recombinant Human TSC2, His-tagged	E.coli	His		Inquiry
Human	TSC2-35H	Recombinant Human TSC2 protein, His-tagged	E.coli	His	1459-1807 aa	$319 / 25ug
Rat	TSC2-6310R	Recombinant Rat TSC2 Protein	Mammalian Cell	His		Inquiry
Rat	TSC2-5967R-B	Recombinant Rat TSC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	TSC2-5967R	Recombinant Rat TSC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	TSC2-4633Z	Recombinant Zebrafish TSC2	Mammalian Cell	His		Inquiry
Zebrafish	TSC2-6386Z	Recombinant Zebrafish TSC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TSC2 Related Research Area
TSC2 Related Signal Pathway

TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	KIT;SYK;GNA12;CYTH2;AGTR1B;KITLG;GRM8;PPAP2B;CYTH3
p signaling pathway	RRM2B;GADD45AB;ATM;TP53I3;SESN2;APAF1;CCNG2;CASP3A;TP73
mTOR signaling pathway	RRAGCA;DEPDC6;EIF4E1B;IGF1;PIK3R2;RPS6KAL;RPS6KA6;VEGFAA;TNF
PIK-Akt signaling pathway	G6PC2;GNG10;PPP2R2D;FGFR4;PHLPP2;CCND1;PRLR;LAMA1;FGF10
AMPK signaling pathway	PPP2CB;PIK3CD;RAB2A;PDPK1;MLYCD;PPP2CA;PPP2R2C;FBP1;EEF2K
Insulin signaling pathway	TSC1B;G6PCA.1;TSC2;FLOT1;PPP1R3DA;MKNK2B;PRKACBA;CALM1;ACACB
Thyroid hormone signaling pathway	ATP1B1;MED13;ATP1B3;HDAC2;FOXO1;MED14;PLCB3;RAF1;ATP1B2
Choline metabolism in cancer	PLD1;SOS1;FOS;PIK3R3;PRKCG;MAP2K2;CHKA;SLC22A2;DGKA

TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

Function	Related Protein
14-3-3 protein binding	ARRB2;RPTOR;SRPK2;PPP1R12A;PRKCZ;KCNH1;YWHAQ;ZFP36;IRS2
GTPase activator activity	ASAP2;ARHGAP15;RASAL3;ELMOD1;ARHGEF12;RGS5;TBC1D8;GIT2B;ARHGAP35
phosphatase binding	CARHSP1;PPP1R27;MAPK3;SYTL2;DLG3;PPP1R37;DLG1L;TSC2;MAST2
protein binding	SNAP47;TTR;MRPL12;DDX39A;ABCF1;AEBP2;HIF1A;GNMT;EXOC4
protein homodimerization activity	COMMD1;NLGN4X;TSG101;UGT1A6;GJC3;TIRAP;DMRTA2;PRMT2;TENM2
small GTPase binding	GDI2;FGD4;RNF152;FGD1;FGD3;FGD2;FLNA;PEX5L;ERRFI1

TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.

YWHAB; YWHAZ

Tumor Suppressors

Renal Markers