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TUBB3

  • Official Full Name

    tubulin, beta 3 class III

  • Overview

    This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
  • Synonyms

    TUBB3; tubulin, beta 3 class III; tubulin, beta 3; tubulin beta-3 chain; beta 4; class III beta tubulin; tubulin beta-III; tubulin beta-4 chain; class III beta-tubulin; CDCBM; TUBB4; beta-4; CFEOM3A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TUBB3-203HFL Active Recombinant Full Length Human TUBB3 Protein, C-Flag-tagged Mammalian cells Flag
Human TUBB3-1305H Recombinant Human TUBB3 protein, His & GST-tagged E.coli His/GST Tyr222~Glu438
Human TUBB3-3487H Recombinant Human TUBB3, GST-tagged E.coli GST 43-258aa
Human TUBB3-7552H Recombinant Human TUBB3, His-tagged E.coli His 1-450aa
Human TUBB3-648HCL Recombinant Human TUBB3 293 Cell Lysate HEK293 N/A
Human TUBB3-5204H Recombinant Human TUBB3 protein, GST-tagged E.coli GST 1-210aa
Human TUBB3-2277H Recombinant Human TUBB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TUBB3-005H Recombinant Human TUBB3 protein, His-tagged E. coli His 44-259 aa
Human TUBB3-5059H Recombinant Human TUBB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TUBB3-5530H Recombinant Human TUBB3 Protein E.coli Tag Free
Human TUBB3-2277H-B Recombinant Human TUBB3 Protein Pre-coupled Magnetic Beads HEK293
Human TUBB3-5531H Recombinant Human TUBB3 Protein (Met1-Lys450), C-His tagged E.coli C-His Met1-Lys450
Mouse TUBB3-17618M Recombinant Mouse TUBB3 Protein Mammalian Cell His
Mouse Tubb3-6728M Recombinant Mouse Tubb3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TUBB3-9761M Recombinant Mouse TUBB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TUBB3-9761M-B Recombinant Mouse TUBB3 Protein Pre-coupled Magnetic Beads HEK293
Rat TUBB3-6363R Recombinant Rat TUBB3 Protein Mammalian Cell His
Rat TUBB3-6019R-B Recombinant Rat TUBB3 Protein Pre-coupled Magnetic Beads HEK293
Rat TUBB3-6019R Recombinant Rat TUBB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TUBB3-3238C Recombinant Chicken TUBB3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TUBB3 Related Articles
  • TUBB3 Related Research Area

TUBB3 involved in several pathways and played different roles in them. We selected most pathways TUBB3 participated on our site, such as Delta-Notch Signaling Pathway, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Delta-Notch Signaling PathwayWDR12;TLE1;YY1A;CNTF;YY1;JAG1;SAP30;NOV;HES6
Gene ExpressionSSRP1A;ZNF606;ZNF776;ZNF543;MTERF;WHSC2;LAMTOR1;KRBA1;TCEB3
Generic Transcription PathwayZNF596;ZNF713;NKX2;MED25;ZNF484;ZNF718;MED15;ZNF446;ZNF205
NOTCH1 Intracellular Domain Regulates TranscriptionTLE1;TLE4;HEY1;HEYL;TUBB3;TLE3;TLE2;HEY2
NOTCH2 intracellular domain regulates transcription
Notch Signaling PathwayADAM17;MIB1;NCSTN;DTX3;MYCBP;RFNG;HDAC2;HDAC1;DTX2
Notch-HLH transcription pathway

TUBB3 has several biochemical functions, for example, peptide antigen binding, protein kinase binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBB3 itself. We selected most functions TUBB3 had, and list some proteins which have the same functions with TUBB3. You can find most of the proteins on our site.

Function Related Protein
peptide antigen bindingHLA-G;HLA-DRB3;TAP1;TUBB3;CLEC4M;MHC1ZKA;HLA-E;HLA-DQA1;MR1
protein kinase bindingCDK5;PKD1;DNM1;MAPK6;PFKFB2;CDK5R1;GYS1;RAB11FIP2;LSM2
transcription coactivator activityTRIM24;PMF1;NR1I2;SERTAD2;FUS;WNT3A;RIPK3;SOX10;SMARCA2

TUBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBB3.

TUBA1B; TERF1; LRRK2; MAP3K3; TK1; RCC1; ANXA7; CDKN1A; TPTE; SMN1; 15-deoxy-delta(12,14; midostaurin; ere_dna; SYNCRIP; PEX14

Zen, Y; Britton, D; et al. Tubulin beta-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma. HISTOPATHOLOGY 65:784-792(2014).
Jouhilahti, EM; Visnapuu, V; et al. Oral soft tissue alterations in patients with neurofibromatosis. CLINICAL ORAL INVESTIGATIONS 16:551-558(2012).
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