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TYROBP

  • Official Full Name

    Tyro protein tyrosine kinase binding protein

  • Overview

    This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    TYROBP; Tyro protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; DAP12; DNAX-activation protein 12; killer cell activating receptor-associated protein; Karap;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TYROBP-613HCL Recombinant Human TYROBP 293 Cell Lysate HEK293 N/A
Human TYROBP-614HCL Recombinant Human TYROBP 293 Cell Lysate HEK293 N/A
Human TYROBP-519H Recombinant Human TYROBP Protein, His&GST-tagged E.coli N-His&GST Leu22-Lys113
Human TYROBP-4167H Recombinant Human TYROBP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TYROBP-1569HFL Recombinant Full Length Human TYROBP Protein, C-Flag-tagged Mammalian cells Flag
Human TYROBP-2287H Recombinant Human TYROBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TYROBP-2287H-B Recombinant Human TYROBP Protein Pre-coupled Magnetic Beads HEK293
Mouse TYROBP-17675M Recombinant Mouse TYROBP Protein Mammalian Cell His
Mouse Tyrobp-6759M Recombinant Mouse Tyrobp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TYROBP-9801M Recombinant Mouse TYROBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TYROBP-9801M-B Recombinant Mouse TYROBP Protein Pre-coupled Magnetic Beads HEK293
Rat TYROBP-6383R Recombinant Rat TYROBP Protein Mammalian Cell His
Rat TYROBP-6039R-B Recombinant Rat TYROBP Protein Pre-coupled Magnetic Beads HEK293
Rat TYROBP-6039R Recombinant Rat TYROBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL7785HF Recombinant Full Length Human Tyro Protein Tyrosine Kinase-Binding Protein(Tyrobp) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-113)
Mus musculus (Mouse) RFL1735MF Recombinant Full Length Mouse Tyro Protein Tyrosine Kinase-Binding Protein(Tyrobp) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-114)
Pan troglodytes (Chimpanzee) RFL22251PF Recombinant Full Length Pan Troglodytes Tyro Protein Tyrosine Kinase-Binding Protein(Tyrobp) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-113)
Rhesus Macaque TYROBP-5044R Recombinant Rhesus monkey TYROBP Protein, His-tagged Mammalian Cell His
Rhesus Macaque TYROBP-4857R Recombinant Rhesus Macaque TYROBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TYROBP-4857R-B Recombinant Rhesus Macaque TYROBP Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TYROBP-5873Z Recombinant Zebrafish TYROBP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TYROBP Related Research Area

TYROBP involved in several pathways and played different roles in them. We selected most pathways TYROBP participated on our site, such as Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYROBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationRAC1;NFKB1;CSF1;TRAF6;LILRB1;IFNB1;NFKB2;GRB2;LILRB5
Natural killer cell mediated cytotoxicityKIR2DL1;TNFSF10;KIR2DL4;Casp3;ULBP3;SAMD3;PTPN11;Fasl;SH2D1B

TYROBP has several biochemical functions, for example, identical protein binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYROBP itself. We selected most functions TYROBP had, and list some proteins which have the same functions with TYROBP. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingRNF4;RIPK1;TNN;TRIM39;PCNA;UBQLN1;CLDN15;USP2;BNIP3
protein bindingTHAP3;ULK1;SERPINB9;SPINK2;PEX6;CCDC120;MXI1;OAS3;UBE2D4
receptor bindingLTA;ITGA1;CAV1;CHRNA10;CXCL12;FGF12B;NXPH1;ZAP70;NPPB
receptor signaling protein activityGNAZ;ADRB1;TRAIP;ARF1;IFITM1;RAF1A;DAXX;NSMAF;DOK1

TYROBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYROBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TYROBP.

KLRC2; SIRPB1; SYK; SIGLEC14; KIR2DS3; purL; gmhB; astD

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