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Tek

  • Official Full Name

    TEK tyrosine kinase, endothelial

  • Overview

    This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
  • Synonyms

    TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; venous malformations, multiple cutaneous and mucosal; Angiopoietin-1 receptor; EC=2.7.10.1; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; OTTHUMP00000021167; OTTHUMP00000227067; OTTHUMP00000227068; OTTHUMP00000227069; soluble TIE2 variant 1; soluble TIE2 variant 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Zebrafish
  • Baculovirus-Infected Sf9 Cells
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • His
  • DDK|His
  • Fc
  • Fc Chimera
  • Fc|His
  • Flag
  • GST
  • hFc
  • hIgG
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TEK-703H Active Recombinant Human TEK, Fc-tagged Human Cell Fc
Human TEK-40H Active Recombinant Human TEK protein, GST-tagged Insect Cell GST
Human TEK-41H Active Recombinant Human TEK protein, GST-tagged Insect Cell GST
Human TEK-42H Active Recombinant Human TEK protein, GST-tagged Insect Cell GST
Human TEK-702H Active Recombinant Human TEK, Fc-tagged, Biotinylated Human Cell Fc
Human TEK-243H Active Recombinant Human TEK(R849W)(771-end) Mutation Protein, N-His-tagged Sf21 His 771-end
Human TEK-244H Active Recombinant Human TEK(Y1108F)(771-end) Mutation Protein, N-His-tagged Sf21 His 771-end
Human TEK-2123H Active Recombinant Human TEK protein, Fc-tagged HEK293 Fc Ala 23 - Leu 748
Human TEK-245H Active Recombinant Human TEK(Y897S)(771-end) Mutation Protein, N-His-tagged Sf21 His 771-end
Human TEK-246H Active Recombinant Human TEK(771-end) Protein, N-His-tagged Sf21 His 771-end
Human TEK-153H Recombinant Human TEK, Fc-His tagged Human Cell Fc/His
Human TEK-39H Recombinant Human TEK protein, GST-tagged Insect Cell GST
Human TEK-84H Recombinant Human TEK protein, Flag-tagged, Biotinylated Insect Cell Flag
Human TEK-469H Recombinant Human TEK Mammalian Cell His
Human TEK-30629TH Recombinant Human TEK, Fc-tagged Fc
Human TEK-1311H Recombinant Human TEK Tyrosine Kinase, Endothelial Insect Cell N/A
Human TEK-75H Recombinant Human TEK Tyrosine Kinase, Endothelial, Fc-tagged Insect Cell Fc
Human TEK-445H Recombinant Human TEK Tyrosine Kinase, Endothelial, GST-tagged, Active Sf9 Insect Cell GST
Human TEK-3177H Recombinant Human TEK, GST-tagged E.coli GST C-term-346aa
Human TEK-1687H Recombinant Human TEK Tyrosine Kinase, Endothelial Mammalian cells N/A
Human TEK-547H Recombinant Human TEK Tyrosine Kinase, Endothelial, His-tagged Sf9 Insect Cell His
Human TEK-390H Recombinant Human TEK Tyrosine Kinase, Endothelial, His-tagged Sf9 Insect Cell His
Human TEK-7296H Active Recombinant Human TEK protein(Gln771-Ala1124), His&GST-tagged Insect Cells N-His&GST Gln771-Ala1124
Human TEK-22H Recombinant Human TIE2 (A1124V), GST-tagged Sf9 Insect Cell GST
Human TEK-31525TH Recombinant Human TEK, His-tagged His
Human TEK-154H Active Recombinant Human TEK protein, His-tagged HEK293 His Met1-Lys745
Human TEK-535H Recombinant Human TEK protein, His & T7-tagged E.coli His/T7 Met1~Met116 (Accession # Q02763)
Human TEK-18H Recombinant Human TIE2 (P883A), GST-tagged Sf9 Insect Cell GST
Human TEK-21H Recombinant Human TIE2 (Y1108F), GST-tagged Sf9 Insect Cell GST
Human TEK-17H Recombinant Human TIE2 (R849W), GST-tagged Sf9 Insect Cell GST
Human TEK-585H Recombinant Human TEK Protein, DDK/His-tagged HEK293 DDK/His
Human TEK-19H Recombinant Human TIE2 (Y897C), GST-tagged Sf9 Insect Cell GST
Human TEK-20H Recombinant Human TIE2 (Y897S), GST-tagged Sf9 Insect Cell GST
Human TEK-415HCL Recombinant Human TEK cell lysate Insect Cell N/A
Human TEK-425H Recombinant Human TEK protein, His-tagged, Biotinylated HEK293 His Met1-Lys745
Human TEK-036H Active Recombinant Human TEK Protein, hIgG/His-tagged Insect cells hIgG/His
Human TEK-1547H Recombinant Human TEK Protein (Ala23-Lys745), N-His tagged E.coli N-His Ala23-Lys745
Human TEK-2758H Recombinant Human TEK Protein, His-tagged E.coli N-His Met1-Ile465
Human TEK-2595H Active Recombinant Human TEK protein Baculovirus-Infected Sf9 Cells N/A Lys808-Ala1124
Human TEK-2653H Active Recombinant Human TEK protein, His&hFc-tagged HEK293 His&hFc Met1-Lys745
Human TEK-2054H Recombinant Human TEK Protein, Fc/His-tagged HEK293 Fc/His Ala23-Lys745
Human TEK-008H Active Recombinant Human TEK Protein, hIgG/His-tagged Insect Cells hIgG/His 23-748aa
Human TEK-4171H-B Recombinant Human TEK Protein Pre-coupled Magnetic Beads HEK293
Human TEK-5126H Recombinant Human TEK Protein (Met1-Lys745), C-His tagged Mammalian cells C-His Met1-Lys745
Human TEK-4171H Recombinant Human TEK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TEK-6408H Recombinant Human TEK Protein (23-745), His tagged E.coli His 23-745
Mouse Tek-490M Active Recombinant Mouse Tek, Fc Chimera Mammalian cells Fc Chimera
Mouse Tek-959M Active Recombinant Mouse Tek Protein, Fc-tagged HEK293 Fc
Mouse Tek-1779M Recombinant Mouse Endothelial-specific Receptor Tyrosine Kinase Mammalian cells N/A
Mouse Tek-73M Recombinant Mouse Tek protein, His-tagged Insect Cell His
Mouse Tek-89M Recombinant Mouse Tek, Fc-tagged CHO Fc
Mouse Tek-7419M Active Recombinant Mouse Tek protein(Gln770-Ala1122), His&GST-tagged Insect Cells N-His&GST Gln770-Ala1122
Mouse Tek-7418M Active Recombinant Mouse Tek protein, His-tagged HEK293 His Met1-Lys744
Mouse TEK-404MCL Recombinant Mouse TEK cell lysate Insect Cell N/A
Mouse TEK-1511MCL Recombinant Mouse TEK cell lysate Human Cell N/A
Mouse Tek-148M-B Recombinant Mouse Tek Protein Pre-coupled Magnetic Beads HEK293
Mouse Tek-148M Recombinant Mouse Tek Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tek-7346M Active Recombinant Mouse Tek Protein, His-tagged Insect Cell His
Mouse Tek-7344M Recombinant Mouse Tek Protein, Fc-tagged CHO Fc
Mouse TEK-2215M Active Recombinant Mouse TEK protein, Fc-tagged HEK293 Fc Ala 23 - Leu 746
Rat Tek-675R Active Recombinant Rat Tek, Fc Chimera Mammalian cells Fc Chimera
Rat Tek-537R Recombinant Rat Tek protein, His & GST-tagged E.coli His/GST Cys44~Glu341 (Accession # D3ZCD0)
Rat Tek-1360R Recombinant Rat Tek, Fc tagged Human Cell Fc
Rat TEK-1707RCL Recombinant Rat TEK cell lysate Human Cell N/A
Rat Tek-28R Recombinant Rat Tek Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tek-28R-B Recombinant Rat Tek Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus TEK-212C Active Recombinant Cynomolgus TEK protein, hFc-tagged HEK293 hFc Met1-Lys745
Cynomolgus TEK-0776C Recombinant Cynomolgus TEK protein, His-tagged HEK293 His Ala23-Lys745
Cynomolgus Monkey TEK-155C Recombinant Cynomolgus TEK, Fc tagged Human Cell His
Cynomolgus Monkey TEK-1065CCL Recombinant Cynomolgus TEK cell lysate Human Cell N/A
Rhesus TEK-996R Recombinant Rhesus TEK Protein (Met1-Lys745), His-tagged HEK293 His Met1-Lys745
Zebrafish tek-1020Z Active Recombinant Zebrafish tek Protein, Fc Chimera Mammalian cells Fc
Zebrafish TEK-9028Z Recombinant Zebrafish TEK Mammalian Cell His
Zebrafish tek-1257Z Recombinant Zebrafish tek Protein, His&GST-tagged E.coli N-His&GST Val22-Ala312
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tek Related Articles

Tek involved in several pathways and played different roles in them. We selected most pathways Tek participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tek were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFIGF;PAK3;RAB5C;FGF9;PLA2G2F;PRKCA;Kitl;RAP1A;PRKACA
Rap signaling pathwayPIK3CB;CALML5;RAPGEF5;PRKCG;MAPK12;FGF6;FGF1;ANGPT1;FGF10
HIF- signaling pathwayEIF4E2;NOX1;NOX3;ANGPT1;HK3;PRKCG;HMOX1;MTOR;RPS6
PIK-Akt signaling pathwayGNG4;HRAS;FGFR1;CCNE1;ITGB5;IFNA10;OSM;ITGA2B;IKBKG
Rheumatoid arthritisACP5;TNFSF13B;TGFB2;Ccl12;CXCL12;HLA-DOB;CXCL6;CCL3L3;ATP6V1F

Tek has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tek itself. We selected most functions Tek had, and list some proteins which have the same functions with Tek. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGTF2F2;PEX1;CDK13;EPHA1;MAST4;EPRS;ATP2B4;ATP6V1B2;YTHDC2
growth factor bindingHTRA1B;OSMR;NKD2;LIFR;SDCBP;ACVR2B;RHBDF1;TEK;RPL37
protein bindingVRK2;AURKA;TIPRL;SH2D3A;RNF41;KLHDC3;CCNB1;TRIM16;MUS81
protein kinase activityMAP4K3;SRC;ADRBK2;EPHA4;CCL5;MAP3K11;BMPR1BB;TGFBR1B;OXSR1A
protein tyrosine kinase activityERBB2;TNK1;ABL2;BCR;FGFR1A;MAP2K6;EGFR;MET;ZNF143B
receptor activityCXCR3;RTN4RL2;LILRA2;NOTCH1A;CUL5;NR2C2;RTN4RL1;SLC40A1;OGFRL2
transmembrane receptor protein tyrosine kinase activityFGFR1B;EPHB2B;MERTK;ROR1;ROR2;EPHA2A;TIE1;KDRL;EPHB3A

Tek has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tek here. Most of them are supplied by our site. Hope this information will be useful for your research of Tek.

ANGPT2; SHC1; Angpt2; PTPRC; PKM; PTPRB; PTPRG; PTPN12; PTPRJ; PTPRK

Chen, JY; Liu, ZJ; et al. Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells. PLOS ONE 9:-(2014).
Kobayashi, M; Shelley, WC; et al. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf beta for their development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:12151-12156(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does the TEK gene influence vascular development during embryogenesis, and what are the key molecular players involved? 09/26/2021

The TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.

What role does the TEK gene play in pathological angiogenesis, particularly in diseases like cancer? 06/15/2020

The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.

How does the TEK gene contribute to the modulation of vascular permeability? 12/07/2019

The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.

How does the TEK gene contribute to the maintenance of vascular quiescence, and what molecular processes are involved? 08/04/2019

The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.

How does the TEK gene participate in the regulation of immune responses in the context of vascular inflammation? 03/05/2018

The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.

Customer Reviews (3)

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Reviews
06/07/2020

    Outstanding service! Staff expertise helped us choose the perfect protein.

    10/31/2019

      Seamless delivery process—ordered, received, and ready for experiments.

      03/14/2018

        Courteous and efficient customer service made our purchase hassle-free.

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