THBS1
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Official Full Name
thrombospondin 1
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Overview
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008] -
Synonyms
THBS1; thrombospondin 1; TSP; THBS; TSP1; TSP-1; THBS-1; thrombospondin-1; thrombospondin-1p180;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Cattle
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human plasma
- Human Platelet
- Insect Cell
- Mammalian Cell
- Mammalian cells
- NS0
- Yeast
- Flag
- His
- His (Fc)
- Avi
- GST
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | THBS1-31514TH | Native Human THBS1 | N/A | |||
Human | THBS1-31516TH | Recombinant Human THBS1 | E.coli | N/A | ||
Human | THBS1-185H | Recombinant Human Thrombospondin 1 | Insect Cell | N/A | ||
Human | THBS1-31513TH | Recombinant Human THBS1 protein, glycosylated | Insect Cell | N/A | ||
Human | THBS1-2657H | Recombinant Human THBS1 protein, His-tagged | E.coli | His | Ser24~Thr221 | |
Human | THBS1-1101HCL | Recombinant Human THBS1 293 Cell Lysate | HEK293 | N/A | ||
Human | THBS1-355H | Recombinant Human THBS1 Protein, His-tagged | HEK293 | His | Asn19-Pro1170 | |
Human | THBS1-31515TH | Native Human THBS1 | N/A | |||
Human | THBS1-4946H | Native Human Thrombospondin protein | Human Platelet | N/A | ||
Human | THBS1-5524H | Natve Human Thrombospondin | Human plasma | N/A | ||
Human | THBS1-200H | Recombinant Human THBS1 protein, His-GST-tagged | E.coli | His/GST | Asn19~Cys546 | |
Human | THBS1-894H | Recombinant Human THBS1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | THBS1-3321H | Recombinant Human THBS1 protein, His-tagged | E.coli | His | 25-250 aa | |
Human | THBS1-51H | Recombinant Human THBS1 Protein | E.coli | 19-600aa | ||
Human | THBS1-60HFL | Recombinant Full Length Human THBS1 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | THBS1-5236H | Recombinant Human THBS1 protein, His-tagged | E.coli | His | 19-344aa | |
Human | THBS1-2189H-B | Recombinant Human THBS1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | THBS1-2189H | Recombinant Human THBS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | THBS1-08H | Active Recombinant Human THBS1 Protein, His-tagged | NS0 | His | 19-1170 | |
Mouse | Thbs1-659M | Active Recombinant Mouse Thbs1 | Mammalian cells | N/A | ||
Mouse | Thbs1-2658M | Recombinant Mouse Thbs1 protein, His-tagged | E.coli | His | Ile61~Ile259 (Accession # P35441) | |
Mouse | Thbs1-2659M | Recombinant Mouse Thbs1 protein, His-tagged | E.coli | His | Arg515~Asp671 (Accession # P35441) | |
Mouse | Thbs1-2660M | Recombinant Mouse Thbs1 protein, His-tagged | E.coli | His | Phe957~Lys1129 (Accession # P35441) | |
Mouse | Thbs1-10619M-B | Recombinant Mouse Thbs1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Thbs1-10619M | Recombinant Mouse Thbs1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Thbs1-3576M | Recombinant Mouse Thbs1 protein, His-tagged | E.coli | His | 19-350aa | |
Mouse | Thbs1-5531M | Recombinant Mouse Thbs1 protein, His-tagged | Yeast | His | 19-350aa | |
Mouse | Thbs1-6407M | Recombinant Mouse Thbs1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | Thbs1-2661R | Recombinant Rat Thbs1 protein, His-tagged | E.coli | His | Pro71~Ile259 | |
Rat | Thbs1-2662R | Recombinant Rat Thbs1 protein, His-tagged | E.coli | His | Asn327~Ala478 (Accession # Q71SA3) | |
Rat | Thbs1-2663R | Recombinant Rat Thbs1 protein, His-tagged | E.coli | His | Phe957~Lys1129 (Accession # Q71SA3) | |
Rat | Thbs1-2664R | Recombinant Rat Thbs1 protein, His-tagged | E.coli | His | Gly511~Ser670 (Accession # Q71SA3) | |
Cattle | THBS1-2656C | Recombinant Cattle THBS1 protein, His & T7-tagged | E.coli | His/T7 | Asn65~Cys270 (Accession# Q28178) | |
Chicken | THBS1-4319C | Recombinant Chicken THBS1 | Mammalian Cell | His | ||
CDA101 | Thrombospondin-1 Peptide Antigen | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- THBS1 Related Research Area
THBS1 involved in several pathways and played different roles in them. We selected most pathways THBS1 participated on our site, such as Rap signaling pathway, p signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Rap signaling pathway | PIK3CB;PLCG1;PLCB1;PRKCA;GNAS;GRIN2B;PDGFC;PFN2;NGF |
p signaling pathway | GADD45AB;IGF1;CCNG1;STEAP3;MDM4;PERP;BAI1;CCNE1;PPM1DB |
Phagosome | ACTG1;ATP6V1E1;ATP6V1F;MRC1;ATP6V1D;MRC2;ATP6V1H;HLA-DMB;FCGR3B |
PIK-Akt signaling pathway | NOS3;ATF4;TSC2;IFNA4;FGF22;THBS4;TLR2;KITLG;FGF20 |
TGF-beta signaling pathway | ACVR1L;BAMBIB;SP1;ID4;BAMBI;LTBP1;TNF;TGFBR1;ACVR2AA |
Focal adhesion | ITGB4;ROCK2;FLNB;PIK3R2;HRASA;MYL5;VCL;SOS1;BCL2A |
ECM-receptor interaction | ITGB1B.2;LAMA3;GP1BA;SV2C;Reln;CD36;COL6A3;COL1A2;DAG1 |
Malaria | SDC1;TLR2;THBS4;THBS1;KLRK1;CSF3;HBA2;TGFB2;KLRB1 |
Proteoglycans in cancer | WNT3;WNT2;WNT8B;AKT1;PTPN6;ARAF;PIK3CG;PIK3R2;HSPG2 |
MicroRNAs in cancer | HOXD10;CDC25B;VIM;TPM1;SIRT1;TGFB2;ZEB1;HMGA2;DNMT3B |
Bladder cancer | RPS6KA5;MDM2;BRAF;CDK4;HRAS;CDKN2A;FGFR3;TRP53;MAP2K1 |
THBS1 has several biochemical functions, for example, calcium ion binding, collagen V binding, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS1 itself. We selected most functions THBS1 had, and list some proteins which have the same functions with THBS1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
calcium ion binding | MMP8;ANXA3B;F7;CDH24;CDH13;SLC25A23B;CABP4;PCDHA8;CALML5 |
collagen V binding | THBS1;ECM2 |
fibrinogen binding | MFAP2;ITGA2B;FBLN1;THBS1 |
fibroblast growth factor binding | FGFR1;RPS19;FIBPA;KLB;FGFBP1;FIBPB;TGFBR3;S100A13;FGFRL1 |
fibronectin binding | ITGA4;SDC4;ITGB3;MFAP2;LACRT;LRRC15;IGFBP5B;ITGB1A;FSTL3 |
glycoprotein binding | FLNA;DNAJC5;LGALS1;LACRT;ERBB2;LCK;STX1A;PTBP3;ACE2 |
heparin binding | CCL7;FGFRL1;FGF1A;NRP2;ZNF146;SLIT1A;FMODA;APP;IMPG2 |
identical protein binding | SMURF2;VWF;MLL1;PLIN5;COL18A1;KCNJ10;STAT2;MVK;HTT |
integrin binding | NISCH;L1CAM;SFRP2;Tcam1;SEMA7A;PTPN2;ACTN4;ADAM2;SYK |
laminin binding | LGALS2A;TINAGL1;NID1;BCAM;NCL;LGALS3;THBS1;ACHE;GPC1 |
low-density lipoprotein particle binding | SORL1;COLEC12;CRP;ANKRA2;SCARF1;LIPC;MSR1;THBS1;SCARB1 |
phosphatidylserine binding | OSBPL8;CD300A;JPH2;RASGRP1;GAS6;RPE65;RS1;AP1S2;SYT4 |
protein binding | KLHL22;TGFBRAP1;LILRA4;CTTN;HNRNPR;ATF6B;BRMS1;NCOA5;FAM123A |
proteoglycan binding | UBE4A;CECR1;CTSK;CTSB;NID1;SLIT2;CTSS;COL5A1;FCN2 |
transforming growth factor beta binding | THBS1;CD109;TGFBR1;ACVR1;ITGAV;ACVRL1;TGFB3;LTBP4;ENG |
THBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS1.
PCOLCE; TGFB1; PLEK; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_i_human; collagen_xi_human; collagen_vi_human; FN1; APP; Col11a1; BGN; TGM2
- Q&As
- Reviews
Q&As (7)
Ask a questionTHBS1 is widely expressed but is upregulated in response to injury or in certain disease states.
It can either promote or inhibit cancer progression, depending on the context.
It binds to extracellular matrix components, influencing cell attachment and signaling.
THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.
Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.
THBS1 modulates cell adhesion, proliferation, and migration.
Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.
Customer Reviews (3)
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