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THBS1

  • Official Full Name

    thrombospondin 1

  • Overview

    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • Synonyms

    THBS1; thrombospondin 1; TSP; THBS; TSP1; TSP-1; THBS-1; thrombospondin-1; thrombospondin-1p180;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human plasma
  • Human Platelet
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human THBS1-31514TH Native Human THBS1 N/A
Human THBS1-31516TH Recombinant Human THBS1 E.coli N/A
Human THBS1-185H Recombinant Human Thrombospondin 1 Insect Cell N/A
Human THBS1-31513TH Recombinant Human THBS1 protein, glycosylated Insect Cell N/A
Human THBS1-2657H Recombinant Human THBS1 protein, His-tagged E.coli His Ser24~Thr221
Human THBS1-1101HCL Recombinant Human THBS1 293 Cell Lysate HEK293 N/A
Human THBS1-355H Recombinant Human THBS1 Protein, His-tagged HEK293 His Asn19-Pro1170
Human THBS1-31515TH Native Human THBS1 N/A
Human THBS1-4946H Native Human Thrombospondin protein Human Platelet N/A
Human THBS1-5524H Natve Human Thrombospondin Human plasma N/A
Human THBS1-200H Recombinant Human THBS1 protein, His-GST-tagged E.coli His/GST Asn19~Cys546
Human THBS1-894H Recombinant Human THBS1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human THBS1-3321H Recombinant Human THBS1 protein, His-tagged E.coli His 25-250 aa
Human THBS1-51H Recombinant Human THBS1 Protein E.coli 19-600aa
Human THBS1-60HFL Recombinant Full Length Human THBS1 Protein, C-Flag-tagged Mammalian cells Flag
Human THBS1-5236H Recombinant Human THBS1 protein, His-tagged E.coli His 19-344aa
Human THBS1-2189H-B Recombinant Human THBS1 Protein Pre-coupled Magnetic Beads HEK293
Human THBS1-2189H Recombinant Human THBS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human THBS1-08H Active Recombinant Human THBS1 Protein, His-tagged NS0 His 19-1170
Mouse Thbs1-659M Active Recombinant Mouse Thbs1 Mammalian cells N/A
Mouse Thbs1-2658M Recombinant Mouse Thbs1 protein, His-tagged E.coli His Ile61~Ile259 (Accession # P35441)
Mouse Thbs1-2659M Recombinant Mouse Thbs1 protein, His-tagged E.coli His Arg515~Asp671 (Accession # P35441)
Mouse Thbs1-2660M Recombinant Mouse Thbs1 protein, His-tagged E.coli His Phe957~Lys1129 (Accession # P35441)
Mouse Thbs1-10619M-B Recombinant Mouse Thbs1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Thbs1-10619M Recombinant Mouse Thbs1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Thbs1-3576M Recombinant Mouse Thbs1 protein, His-tagged E.coli His 19-350aa
Mouse Thbs1-5531M Recombinant Mouse Thbs1 protein, His-tagged Yeast His 19-350aa
Mouse Thbs1-6407M Recombinant Mouse Thbs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Thbs1-2661R Recombinant Rat Thbs1 protein, His-tagged E.coli His Pro71~Ile259
Rat Thbs1-2662R Recombinant Rat Thbs1 protein, His-tagged E.coli His Asn327~Ala478 (Accession # Q71SA3)
Rat Thbs1-2663R Recombinant Rat Thbs1 protein, His-tagged E.coli His Phe957~Lys1129 (Accession # Q71SA3)
Rat Thbs1-2664R Recombinant Rat Thbs1 protein, His-tagged E.coli His Gly511~Ser670 (Accession # Q71SA3)
Cattle THBS1-2656C Recombinant Cattle THBS1 protein, His & T7-tagged E.coli His/T7 Asn65~Cys270 (Accession# Q28178)
Chicken THBS1-4319C Recombinant Chicken THBS1 Mammalian Cell His
CDA101 Thrombospondin-1 Peptide Antigen N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • THBS1 Related Research Area

THBS1 involved in several pathways and played different roles in them. We selected most pathways THBS1 participated on our site, such as Rap signaling pathway, p signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayPIK3CB;PLCG1;PLCB1;PRKCA;GNAS;GRIN2B;PDGFC;PFN2;NGF
p signaling pathwayGADD45AB;IGF1;CCNG1;STEAP3;MDM4;PERP;BAI1;CCNE1;PPM1DB
PhagosomeACTG1;ATP6V1E1;ATP6V1F;MRC1;ATP6V1D;MRC2;ATP6V1H;HLA-DMB;FCGR3B
PIK-Akt signaling pathwayNOS3;ATF4;TSC2;IFNA4;FGF22;THBS4;TLR2;KITLG;FGF20
TGF-beta signaling pathwayACVR1L;BAMBIB;SP1;ID4;BAMBI;LTBP1;TNF;TGFBR1;ACVR2AA
Focal adhesionITGB4;ROCK2;FLNB;PIK3R2;HRASA;MYL5;VCL;SOS1;BCL2A
ECM-receptor interactionITGB1B.2;LAMA3;GP1BA;SV2C;Reln;CD36;COL6A3;COL1A2;DAG1
MalariaSDC1;TLR2;THBS4;THBS1;KLRK1;CSF3;HBA2;TGFB2;KLRB1
Proteoglycans in cancerWNT3;WNT2;WNT8B;AKT1;PTPN6;ARAF;PIK3CG;PIK3R2;HSPG2
MicroRNAs in cancerHOXD10;CDC25B;VIM;TPM1;SIRT1;TGFB2;ZEB1;HMGA2;DNMT3B
Bladder cancerRPS6KA5;MDM2;BRAF;CDK4;HRAS;CDKN2A;FGFR3;TRP53;MAP2K1

THBS1 has several biochemical functions, for example, calcium ion binding, collagen V binding, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS1 itself. We selected most functions THBS1 had, and list some proteins which have the same functions with THBS1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingMMP8;ANXA3B;F7;CDH24;CDH13;SLC25A23B;CABP4;PCDHA8;CALML5
collagen V bindingTHBS1;ECM2
fibrinogen bindingMFAP2;ITGA2B;FBLN1;THBS1
fibroblast growth factor bindingFGFR1;RPS19;FIBPA;KLB;FGFBP1;FIBPB;TGFBR3;S100A13;FGFRL1
fibronectin bindingITGA4;SDC4;ITGB3;MFAP2;LACRT;LRRC15;IGFBP5B;ITGB1A;FSTL3
glycoprotein bindingFLNA;DNAJC5;LGALS1;LACRT;ERBB2;LCK;STX1A;PTBP3;ACE2
heparin bindingCCL7;FGFRL1;FGF1A;NRP2;ZNF146;SLIT1A;FMODA;APP;IMPG2
identical protein bindingSMURF2;VWF;MLL1;PLIN5;COL18A1;KCNJ10;STAT2;MVK;HTT
integrin bindingNISCH;L1CAM;SFRP2;Tcam1;SEMA7A;PTPN2;ACTN4;ADAM2;SYK
laminin bindingLGALS2A;TINAGL1;NID1;BCAM;NCL;LGALS3;THBS1;ACHE;GPC1
low-density lipoprotein particle bindingSORL1;COLEC12;CRP;ANKRA2;SCARF1;LIPC;MSR1;THBS1;SCARB1
phosphatidylserine bindingOSBPL8;CD300A;JPH2;RASGRP1;GAS6;RPE65;RS1;AP1S2;SYT4
protein bindingKLHL22;TGFBRAP1;LILRA4;CTTN;HNRNPR;ATF6B;BRMS1;NCOA5;FAM123A
proteoglycan bindingUBE4A;CECR1;CTSK;CTSB;NID1;SLIT2;CTSS;COL5A1;FCN2
transforming growth factor beta bindingTHBS1;CD109;TGFBR1;ACVR1;ITGAV;ACVRL1;TGFB3;LTBP4;ENG

THBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS1.

PCOLCE; TGFB1; PLEK; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_i_human; collagen_xi_human; collagen_vi_human; FN1; APP; Col11a1; BGN; TGM2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
In which tissues or cell types is THBS1 predominantly expressed? 09/01/2022

THBS1 is widely expressed but is upregulated in response to injury or in certain disease states.

How is THBS1 implicated in cancer progression? 07/10/2021

It can either promote or inhibit cancer progression, depending on the context.

How does THBS1 contribute to cell-matrix interactions? 04/28/2021

It binds to extracellular matrix components, influencing cell attachment and signaling.

What role does THBS1 play in angiogenesis? 09/14/2020

THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.

What therapeutic strategies are being explored targeting THBS1? 03/08/2020

Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.

What is the primary function of THBS1 in cellular processes? 06/17/2018

THBS1 modulates cell adhesion, proliferation, and migration.

Are there known genetic variations in THBS1 associated with specific diseases? 02/13/2018

Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.

Customer Reviews (3)

Write a review
Reviews
05/14/2022

    Quality exceeded my expectations.

    09/08/2021

      Satisfied customer, will return.

      11/21/2020

        Very pure, excellent results.

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