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TIGIT

  • Official Full Name

    T cell immunoreceptor with Ig and ITIM domains

  • Overview

    This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
  • Synonyms

    TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Cynomolgus / Rhesus macaque
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus macaque
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rabbit
  • Rat
  • CHO
  • CHO Cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Mammalian cells
  • C
  • 6His
  • Avi
  • Fc
  • hFc
  • His
  • mFc
  • DDK|His
  • DYKDDDDK
  • Fc Chimera
  • Flag
  • GST
  • His (Fc)
  • His(C
  • ter)
  • His\Avi
  • His|Avi
  • His|T7
  • SUMO
  • HlgG1 Fc
  • human|IgG1|Fc
  • IgG2a Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TIGIT-104H Active Recombinant Human TIGIT Protein, His-tagged CHO His
Human TIGIT-103H Active Recombinant Human TIGIT Protein, Fc-tagged CHO Fc
Human TIGIT-360H Active Recombinant Human TIGIT protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Met 22 - Pro 141
Human TIGIT-356H Active Recombinant Human TIGIT Protein (Met22-Pro141, A103), C-Fc-tagged CHO C-Fc Met22-Pro141, A103
Human TIGIT-105H Active Recombinant Human TIGIT, Fc-tagged CHO Fc
Human TIGIT-107H Active Recombinant Human TIGIT protein, Fc-tagged HEK293 Fc Met1-Pro141
Human TIGIT-2347HB Active Recombinant Human TIGIT protein, His-tagged, Biotinylated HEK293 His
Human TIGIT-454H Active Recombinant Human TIGIT protein(Met1-Pro141), hFc-tagged HEK293 C-hFc Met1-Pro141
Human TIGIT-106H Recombinant Human TIGIT protein, His-tagged HEK293 His Met 22 - Pro 141
Human TIGIT-2347H Active Recombinant Human TIGIT protein, His-tagged HEK293 His Met1-Phe138
Human TIGIT-0631H Active Recombinant Human TIGIT protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Met 22 - Pro 141
Human TIGIT-3232H Recombinant Human TIGIT, GST-tagged E.coli GST 22-141aa
Human TIGIT-135H Recombinant Human TIGIT protein, T7/His-tagged E.coli T7/His
Human TIGIT-108H Active Recombinant Human TIGIT protein, mFc-tagged HEK293 mFc Met 22 - Pro 141
Human TIGIT-2610HCL Recombinant Human TIGIT cell lysate Human Cell N/A
Human TIGIT-1037H Recombinant Human TIGIT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TIGIT-3357H Recombinant Human TIGIT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TIGIT-4486H Recombinant Human TIGIT protein, His-SUMO-tagged E.coli His-SUMO 22-141aa
Human TIGIT-151H Recombinant Human TIGIT Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human TIGIT-163H Recombinant Human TIGIT Protein E.coli N/A
Human TIGIT-23H Recombinant Human TIGIT Protein E.coli
Human TIGIT-106HAF488 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met22-Pro141
Human TIGIT-1031H Recombinant Human TIGIT Protein, DDK/His-tagged HEK293 DDK/His
Human TIGIT-495H Recombinant Human TIGIT protein, His-Avi-tagged HEK293 His-Avi Met22-Pro141
Human TIGIT-306H Recombinant Human TIGIT Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Met22-Pro141
Human TIGIT-106HAF647 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met22-Pro141
Human TIGIT-106HAF555 Recombinant Human TIGIT Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met22-Pro141
Human TIGIT-235HFL Recombinant Full Length Human TIGIT Protein, C-Flag-tagged Mammalian cells Flag
Human TIGIT-184H Recombinant Human TIGIT Protein, His\Avi-tagged Human Cell His\Avi
Human TIGIT-106HF Recombinant Human TIGIT Protein, His-tagged, FITC conjugated HEK293 His Met22-Pro141
Human TIGIT-12H Recombinant Human TIGIT Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Met22-Pro141
Human TIGIT-2617H Active Recombinant Human TIGIT protein, His-tagged HEK293 His Met22-Pro141
Human TIGIT-727H Recombinant Human TIGIT Protein HEK293 244
Human TIGIT-2193H Recombinant Human TIGIT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TIGIT-5739H Active Recombinant Human TIGIT protein(Met1-Pro141), His-tagged HEK293 C-His Met1-Pro141
Human TIGIT-0800H Active Recombinant Human TIGIT protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Met22-Pro141
Human TIGIT-728H Recombinant Human TIGIT Protein, Fc-tagged HEK293 Fc 244
Human TIGIT-434HG Active GMP Recombinant Human TIGIT protein, Fc-tagged HEK293 Fc DNA sequence encoding Human TIGIT(NCBI Reference Sequence: NP_776160.2) was expressed with Fc tag at the C-terminal.
Human TIGIT-729H Recombinant Human TIGIT Protein, IgG2a Fc-tagged HEK293 IgG2a Fc 244
Human TIGIT-2193H-B Recombinant Human TIGIT Protein Pre-coupled Magnetic Beads HEK293
Human TIGIT-5738H Recombinant Human TIGIT Protein (Met22-Pro141), C-His tagged Mammalian cells C-His Met22-Pro141
Human TIGIT-5740H Recombinant Human TIGIT Protein (Met22-Pro141), N-His tagged E.coli N-His Met22-Pro141
Human TIGIT-1089H Recombinant Human TIGIT protein(Met22 - Pro141), His-tagged CHO Cells C-His Met22 - Pro141
Mouse Tigit-693M Active Recombinant Mouse Tigit, Fc Chimera Mammalian cells Fc Chimera
Mouse Tigit-108M Active Recombinant Mouse Tigit, Fc-tagged Human Cell Fc
Mouse TIGIT-1297M Acitve Recombinant Mouse TIGIT protein(Met1-Gly141), mFc-tagged HEK293 C-mFc Met1-Gly141
Mouse Tigit-2348M Recombinant Mouse Tigit, His tagged Human Cell His
Mouse Tigit-109M Active Recombinant Mouse Tigit protein, His-tagged HEK293 His Met 1-Gly 141
Mouse Tigit-110M Recombinant Mouse Tigit protein, Fc-tagged HEK293 human/IgG1/Fc 118
Mouse TIGIT-1420MCL Recombinant Mouse TIGIT cell lysate Human Cell N/A
Mouse TIGIT-0799M Active Recombinant Mouse TIGIT protein, mFc-tagged HEK293 mFc Gly26-Thr143
Mouse Tigit-730M Recombinant Mouse Tigit Protein HEK293 241
Mouse Tigit-7407MAF488 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 357
Mouse Tigit-2348MAF488 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 127
Mouse Tigit-7407MAF555 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 357
Mouse Tigit-731M Recombinant Mouse Tigit Protein, Fc-tagged HEK293 Fc 241
Mouse Tigit-2348MAF555 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 127
Mouse Tigit-2348MAF647 Recombinant Mouse Tigit Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 127
Mouse Tigit-7407MAF647 Recombinant Mouse Tigit Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 357
Mouse Tigit-6821M Recombinant Mouse Tigit Protein (Gly26-Thr143), C-His tagged Mammalian cells C-His Gly26-Thr143
Mouse Tigit-149M Recombinant Mouse Tigit Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tigit-2348MF Recombinant Mouse Tigit Protein, His-tagged, FITC conjugated HEK293 His 127
Mouse Tigit-016M Recombinant Mouse Tigit Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Tigit-6820M Recombinant Mouse Tigit Protein (Gly26-Phe135), C-His tagged Mammalian cells C-His Gly26-Phe135
Mouse Tigit-7407MF Recombinant Mouse Tigit Protein, Fc-tagged, FITC conjugated HEK293 Fc 357
Mouse Tigit-149M-B Recombinant Mouse Tigit Protein Pre-coupled Magnetic Beads HEK293
Mouse Tigit-1440M Recombinant Mouse Tigit protein, His & T7-tagged E.coli His/T7 Gly28~Ser246 (Accession # P86176)
Mouse TIGIT-0803M Active Recombinant Mouse TIGIT protein, His-tagged HEK293 His Gly26-Thr143
Mouse TIGIT-0804M Active Recombinant Mouse TIGIT protein, Fc-tagged HEK293 Fc Gly26-Thr143
Rat TIGIT-205R Recombinant Rat TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc 122
Rat TIGIT-733R Recombinant Rat TIGIT Protein, Fc-tagged HEK293 Fc 242
Rat TIGIT-0802R Active Recombinant Rat TIGIT protein(Met1-Ala138), hFc-tagged HEK293 C-hFc Met1-Ala138
Rat Tigit-1441R Recombinant Rat Tigit protein, His & T7-tagged E.coli His/T7 Met28~Ser227 (Accession # D3ZTQ2)
Rabbit TIGIT-260R Recombinant Rabbit TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc 127
Rabbit TIGIT-732R Recombinant Rabbit TIGIT Protein, Fc-tagged HEK293 Fc 245
Rabbit TIGIT-678R Active Recombinant Rabbit TIGIT protein, Fc-tagged HEK293 Fc Ala 16 - Pro 142
Canine TIGIT-0801C Active Recombinant Canine TIGIT protein, His-tagged HEK293 His Phe17-Pro208
Cynomolgus TIGIT-119C Active Recombinant Cynomolgus TIGIT protein (Met1-Pro209), hFc-tagged HEK293 hFc
Cynomolgus TIGIT-1144C Recombinant Cynomolgus TIGIT Protein (Met1-Pro209), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Pro209
Cynomolgus / Rhesus macaque TIGIT-0798C Active Recombinant Cynomolgus / Rhesus macaque TIGIT protein, mFc-tagged HEK293 mFc Met89-Ile208
Cynomolgus / Rhesus macaque TIGIT-1948C Active Recombinant Cynomolgus / Rhesus macaque TIGIT protein, Fc-tagged HEK293 Fc Met 89 - Ile 208
Cynomolgus Monkey TIGIT-197C Active Recombinant Cynomolgus Monkey TIGIT protein, Fc-tagged HEK293 Fc
Cynomolgus monkey TIGIT-726C Recombinant Cynomolgus monkey TIGIT Protein, Fc-tagged HEK293 Fc 312
Cynomolgus monkey TIGIT-725C Recombinant Cynomolgus monkey TIGIT Protein HEK293 312
Cynomolgus/Rhesus macaque TIGIT-121C Active Recombinant Cynomolgus/Rhesus macaque TIGIT protein, His-tagged HEK293 His Met 89 - Ile 208
Cynomolgus/Rhesus macaque TIGIT-120C Recombinant Cynomolgus/Rhesus macaque TIGIT protein, Fc-tagged HEK293 human/IgG1/Fc 121
Cynomolgus/Rhesus macaque TIGIT-365C Recombinant Cynomolgus/Rhesus macaque TIGIT protein, His-tagged (HPLC-verified) HEK293 His 120
Mus musculus (Mouse) RFL31627MF Recombinant Full Length Mouse T-Cell Immunoreceptor With Ig And Itim Domains(Tigit) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-249)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TIGIT Related Articles
  • TIGIT Related Research Area

TIGIT involved in several pathways and played different roles in them. We selected most pathways TIGIT participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with TIGIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)MAG;PVR;ICAM3;HLA-DRB3;CLDN6;NCAM1;CDH1;CLDN22;PVRL3B

TIGIT has several biochemical functions, for example, cell adhesion molecule binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIGIT itself. We selected most functions TIGIT had, and list some proteins which have the same functions with TIGIT. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingITGB1;DSG2;MSN;CRTAM;CXADR;CADM1;CADM2A;PVRL2L;PVR
protein bindingGSK3A;MAP2K4;ZFP488;CSNK2A2;ITGB3;ATXN3;FES;CDR2;SNRNP70
protein homodimerization activitySDCBP;S100A11;TNNC1;IZUMO1;HNF1A;LMLN;MAP3K5;DDX1;SPATA24
receptor activityKLRB1F;CD244;CALCR;NLGN3A;TEK;CXCR3;VAC14;PLAUR;THBD
receptor bindingPICK1;CXCL10;LRRC4B;TNFSF18;NRG1;RSPO2;FGF12A;SRI;NRG4

TIGIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIGIT here. Most of them are supplied by our site. Hope this information will be useful for your research of TIGIT.

CD226; PVR; PVRL2; PVRL4; PVRL3

Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
Zhang, T; Wang, JH; et al. Increased Expression of TIGIT on CD4(+) T Cells Ameliorates Immune-Mediated Bone Marrow Failure of Aplastic Anemia. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1918-1927(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
In which types of cancers is TIGIT inhibition being investigated? 12/02/2022

TIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.

How is TIGIT relevant in autoimmune diseases? 05/14/2022

TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.

What clinical applications does TIGIT have in cancer therapy? 06/11/2020

TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.

How does TIGIT differ from other immune checkpoint proteins like PD-1 and CTLA-4? 04/22/2020

TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.

Are there any potential side effects associated with TIGIT-targeted therapies? 01/12/2016

As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.

Customer Reviews (3)

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Reviews
11/25/2022

    With its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.

    08/05/2017

      Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.

      05/21/2017

        The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.

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