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U2AF2

Official Full Name

U2 small nuclear RNA auxiliary factor 2
Overview

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
Synonyms

U2AF2; U2 small nuclear RNA auxiliary factor 2; U2AF65; splicing factor U2AF 65 kDa subunit; hU2AF65; U2 auxiliary factor 65 kDa subunit; U2 snRNP auxiliary factor large subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 small nuclear ribonucleoprotein auxiliary factor (65kD);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	U2AF2-3513H	Recombinant Human U2AF2 protein, GST-tagged	E.coli	GST	116-471 aa	$319 / 25ug
Human	U2AF2-718HCL	Recombinant Human U2AF2 lysate	HEK293	N/A		Inquiry
Human	U2AF2-13H	Recombinant Human U2AF2 Protein (141 a.a.-240 a.a.), N-GST-tagged	Wheat Germ	N-GST	141-240	Inquiry
Mouse	U2AF2-17682M	Recombinant Mouse U2AF2 Protein	Mammalian Cell	His		Inquiry
Mouse	U2AF2-9806M-B	Recombinant Mouse U2AF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	U2AF2-9806M	Recombinant Mouse U2AF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

U2AF2 involved in several pathways and played different roles in them. We selected most pathways U2AF2 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region	PAPOLA;CLP1;U2AF2;NUDT21;RNPS1;ZFP473;SRSF11;LSM10;CSTF2
Gene Expression	PEAK1;ZNF256;SUPT5H;HBXIP;ZNF234;ZNF684;SUPT4H1;ZNF643;ZNF254
Processing of Capped Intron-Containing Pre-mRNA	DNAJC8;HNRNPR;BCAS2;THOC4;SLBP;HNRNPH1L;PAPOLA;SF3A3;U2AF2
RNA Polymerase II Transcription	CCNT2A;SLBP;U2AF2;LSM11;CSTF3;LSM10;SRSF11;SUPT16H;PAPOLA
RNA Polymerase II Transcription Termination	U2AF2;THOC4;PAPOLA;CSTF1;CLP1;ZFP473;SRSF11;ZNF473;RNPS1
Spliceosome	HNRNPA1A;HNRPK;RP9;TRA2B;HNRNPU;SFRS3B;HSPA1B;PLRG1;U2AF2B
Transport of Mature Transcript to Cytoplasm	SLBP;NXF1;U2AF2;SFRS3A;SRSF11
Transport of Mature mRNA derived from an Intron-Containing Transcript	SFRS3A;SRSF11;U2AF2

U2AF2 has several biochemical functions, for example, C2H2 zinc finger domain binding, enzyme binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF2 itself. We selected most functions U2AF2 had, and list some proteins which have the same functions with U2AF2. You can find most of the proteins on our site.

Function	Related Protein
C2H2 zinc finger domain binding	GATA2;THAP7;EBF1;U2AF2;WT1;EHMT1;LEF1;TAF9;EHMT2
enzyme binding	RAD9A;DYM;MLL5;EGFR;HOXA9;PUS7;PLCE1;TTN;TARBP2
nucleotide binding	UBE2NA;RBM11;SAFB;GC3;IGF2BP3;ABCB4;ATP1A1A.1;BMPR2A;NT5C3L
poly(A) RNA binding	RBM4B;DDX21;U2AF1;ALDH18A1;CASC3;FTSJ3;EXOSC6;SLIRP;SRP72
poly-pyrimidine tract binding	CPEB2;PTBP1;U2AF2
pre-mRNA 3-splice site binding	SLU7;ZRSR2;U2AF2
protein binding	FBXW11;TFAP2B;TEX10;CDKN2AIP;CARD10;SELL;MIS18BP1;AKR1A1;ABI1

U2AF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF2.

U2AF1; PUF60; SF1