UBA2
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Official Full Name
ubiquitin-like modifier activating enzyme 2
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Overview
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] -
Synonyms
UBA2; ubiquitin-like modifier activating enzyme 2; ARX; SAE2; HRIHFB2115; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
UBA2 involved in several pathways and played different roles in them. We selected most pathways UBA2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism of proteins | FURINB;EIF2B1;TIMM17A;SLC35A1;SEMG1;ACE;SEC22A;GALNT13;MUC21 |
Post-translational protein modification | PREB;ST6GALNAC2;RING1;SPON1B;TRAPPC2L;TRAPPC4;ADAMTS4;MUC5AC;GALNTL5 |
Processing and activation of SUMO | SENP1;SAE1;SENP5;UBA2 |
SUMO is conjugated to E1 (UBA2:SAE1) | UBA2;SAE1 |
SUMO is transferred from E1 to E2 (UBE2I, UBC9) | UBA2;SAE1 |
SUMOylation | RNF2;SAE1;NSMCE1;SMC6;CBX8;NSMCE4A;SENP1;SENP5;SMC5 |
Ubiquitin mediated proteolysis | MGRN1B;CUL4A;CUL3;FBXW11;SOCS1;ANAPC5;CDC27;BRCA1;SIAH2L |
UBA2 has several biochemical functions, for example, ATP binding, SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA2 itself. We selected most functions UBA2 had, and list some proteins which have the same functions with UBA2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | TPK1;ABCG1;PKMYT1;AK5;SRPK1B;GUCY2F;GART;MTHFS;DAPK2 |
SUMO activating enzyme activity | |
enzyme activator activity | MMP16;CTSA;GMFG;TAB1;CLPS;RICTOR;ARL1;PRKCD;CXCL1 |
metal ion binding | MLL1;ANKFY1;PTGS2;PDLIM5B;CYP46A1.1;PRKCBB;UQCRC2B;SDF4;ZNF185 |
protein binding | LARP4B;AOC3;CALM2;CCP110;USP20;GSTM4;CCDC12;PAPOLA;OLFM1 |
protein heterodimerization activity | TIRAP;TAS1R2;MAPK6;HIST2H2AA4;POLE3;ADRa1A;SOX32;TENM2;TFAP2B |
transcription factor binding | BCL3;AGTR2;PRKDC;TCF7L2;STK4;PPP1R13BB;NKX2;H2-AB1;TFDP1 |
UBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA2.
SAE1; g2xkq0_human; SUMO1; UBE2I; MCC; HLA-B; PCBD1; IKBKE; TRAF6; SETX
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that UBA2 expression levels are associated with the occurrence and development of certain diseases, including cancer and neurodegenerative diseases.
In cancer, UBA2 may contribute to tumorigenesis and development by regulating intracellular protein degradation and signal transduction. It could be a potential target for cancer treatment.
The expression level of UBA2 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.
UBA2 can interact with a variety of other proteins, including ubiquitin ligase, proteolytic enzyme, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
The structure of UBA2 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
Therapeutic strategies for UBA2 may include regulating its expression level, inhibiting its enzyme activity, or regulating its associated signal transduction pathways. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, etc.
Customer Reviews (3)
Write a reviewAfter UBA2 was used, the background of the Western blot was very clean and there was no non-specific signal.
The recombinant protein in the pathogenesis of related diseases was evaluated by animal models or in vitro experiments, and the effect was found to be good.
This protein has good stability and consistency during large-scale production.
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