UBA5
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Official Full Name
ubiquitin-like modifier activating enzyme 5
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Overview
This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. -
Synonyms
UBA5; ubiquitin-like modifier activating enzyme 5; UBE1DC1, ubiquitin activating enzyme E1 domain containing 1; ubiquitin-like modifier-activating enzyme 5; FLJ23251; ubiquitin activating enzyme E1 homolog (yeast); 5730525G14Rik; AW240750; FLJ23251UBA5; MGC105565; THIFP1; UBA5 ubiquitin activating enzyme E1 homolog; UBE1DC1; Ubiquitin activating enzyme 5; Ubiquitin activating enzyme E1 domain containing protein 1; Ubiquitin like modifier activating enzyme 5; UFM1 activating enzyme; UFM1-activating enzyme; ubiquitin-activating enzyme 5; UBA5, ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-domain containing 1; ubiquitin-activating enzyme E1 domain-containing protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBA5 Related Research Area
UBA5 involved in several pathways and played different roles in them. We selected most pathways UBA5 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | LAIR1;CTSC;TRIM41;CD200R1;KIF5A;AGO3;SPSB4;SEC23A;ITK |
| Antigen processing: Ubiquitination & | DTX3L;ASB2;FBXO44;HECTD3;FBXO17;KLHL21;UBE2F;TRIM11;BLMH |
| Proteasome degradation | RNF111;RNF14;KLHL21;UCHL3;LRSAM1;DZIP3;UBE2L6;FBXO3;RNF41 |
| Class I MHC mediated antigen processing & | TRIM63;ERAP2;RNF14;ARIH2;WWP1;RBCK1;FBXO44;CYBB;RNF123 |
| presentation | SPSB2;SEC61B;ASB11;WSB1;RNF14;TRIM11;RNF41;NPEPPS;UBR1 |
| Immune System | ASB6;GBP2;CD200R1;EGR1;MGC174857;RAP1GAP2B;KLRB1F;XAF1;AF251705 |
| protein ubiquitylation | UEVLD;RNF216;UBE2E3;UBA5;UBE2U |
UBA5 has several biochemical functions, for example, ATP binding, UFM1 activating enzyme activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA5 itself. We selected most functions UBA5 had, and list some proteins which have the same functions with UBA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | YTHDC2;CSNK1DB;STK19;STK24;UCK2;MTHFD1;JAK2A;TMEM38A;PI4KB |
| UFM1 activating enzyme activity | |
| metal ion binding | TUT1;CALUA;ZNF593;HPDL;TRMT13;ZNF239;ADH8B;ITGB7;ZFP410 |
| protein binding | PRSS3;DOT1L;DLG1;SEPT2;TRP63;ICAM3;FOXB1;HIP1R;PSMB2 |
UBA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA5.
GABARAPL2; UFM1; GABARAP; MAP1LC3C; MAP1LC3B
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