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UBE2A

  • Official Full Name

    ubiquitin-conjugating enzyme E2A

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
  • Synonyms

    UBE2A; ubiquitin-conjugating enzyme E2A; UBC2; HHR6A; MRXSN; RAD6A; MRXS30; ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin-protein ligase A; ubiquitin carrier protein A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Strep
  • SUMO
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE2A-530H Active Recombinant Human UBE2A Protein, His-tagged E.coli His
Human UBE2A-642H Active Recombinant Human UBE2A Protein, His-tagged E.coli His
Human UBE2A-219H Recombinant Human UBE2A, His-tagged E.coli His
Human UBE2A-53H Recombinant Human UBE2A, His-tagged E.coli His
Human UBE2A-849H Recombinant Human UBE2A protein, His-tagged E.coli His Met1-Cys152
Human UBE2A-594HCL Recombinant Human UBE2A 293 Cell Lysate HEK293 N/A
Human UBE2A-595HCL Recombinant Human UBE2A 293 Cell Lysate HEK293 N/A
Human UBE2A-0022H Recombinant Human UBE2A Protein (S2-C152), His/Strep tagged Insect Cell His/Strep S2-C152
Human UBE2A-0021H Recombinant Human UBE2A Protein (S2-C152), Tag Free Insect Cell No tag S2-C152
Mouse UBE2A-3358M Recombinant Mouse UBE2A protein, His-SUMO-tagged E.coli His-SUMO Met1~Cys152
Mouse Ube2a-6779M Recombinant Mouse Ube2a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse UBE2A-3359M Recombinant Mouse UBE2A protein, His-tagged E.coli His Met1~Cys152
Rhesus Macaque UBE2A-5053R Recombinant Rhesus monkey UBE2A Protein, His-tagged Mammalian Cell His
Rhesus Macaque UBE2A-4866R Recombinant Rhesus Macaque UBE2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque UBE2A-4866R-B Recombinant Rhesus Macaque UBE2A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish UBE2A-11433Z Recombinant Zebrafish UBE2A Mammalian Cell His
Chicken UBE2A-6428C Recombinant Chicken UBE2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UBE2A Related Articles
  • UBE2A Related Research Area

UBE2A involved in several pathways and played different roles in them. We selected most pathways UBE2A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisUBE2W;SOCS1A;FLJ11011L;SOCS1;UBE2E3;UBE2I;KLHL9;SKP2;CDC27

UBE2A has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2A itself. We selected most functions UBE2A had, and list some proteins which have the same functions with UBE2A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACSBG1;ABCG1;AK7B;EGFRA;UBE2L3B;ABCG2A;HSP90AB1;ABCB1A;TEP1
protein bindingSMYD2;EDF1;TMEM86B;CLC;SSH1;TXNDC11;TNPO1;HP1BP3;ELK1
ubiquitin conjugating enzyme activityUBE2S;UBE2B;UBE2R2;UBE2Z;CDC34;UBE2D2;UBE2Q1;UBE2G2;UBE2V1
ubiquitin protein ligase activityTOPORS;C12orf51;UBE2S;UBE2T;TRIM32;RAG2;HECW2;PDZRN3B;NHLRC1
ubiquitin protein ligase bindingPIAS4;USP25;UBE2G1B;HSPA9;CDC34;RNF34;UBE2C;PER1;UBE2K
ubiquitin-protein transferase activityMUL1;CBLL1;CMTM2A;RC3H2;PRKCQ;FBXO9;FBXL7;RNF10;UBE2Q2

UBE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2A.

SDCBP; RAD18; RNF20; HAT1; TRIM27; BSG; CRMP1; UBR4; UBR3; UBR1; CMTM2; ETNK2

Bermejo-Alvarez, P; Rizos, D; et al. Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes. REPRODUCTION 141:801-808(2011).
Zhang, H; Zhao, WJ; et al. Characterization of a Moniezia expansa ubiquitin-conjugating enzyme E2 cDNA. MOLECULAR BIOLOGY REPORTS 37:1585-1590(2010).
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