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UBE2J2

Official Full Name

ubiquitin-conjugating enzyme E2, J2
Overview

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Synonyms

UBE2J2; ubiquitin-conjugating enzyme E2, J2; ubiquitin conjugating enzyme E2, J2 (UBC6 homolog, yeast); ubiquitin-conjugating enzyme E2 J2; NCUBE2; Ubc6p; NCUBE-2; Non-canonical ubiquitin-conjugating enzyme 2; UB2J2_HUMAN; UBC6; UBC6 homolog; OTTHUMP00000001907; OTTHUMP00000002077; OTTHUMP00000002078; OTTHUMP00000220526; OTTHUMP00000220527; yeast UBC6 homolog; ubiquitin conjugating enzyme 6; ubiquitin conjugating enzyme E2, J2; ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast); PRO2121;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UBE2J2-244H	Recombinant Human UBE2J2 Protein, His-tagged	E.coli	His		Inquiry
Human	UBE2J2-2485H	Recombinant Human Ubiquitin-Conjugating Enzyme E2, J2, His-tagged	E.coli	His	1-226aa	Inquiry
Human	UBE2J2-1870HCL	Recombinant Human UBE2J2 cell lysate		N/A		Inquiry
Zebrafish	UBE2J2-5621Z	Recombinant Zebrafish UBE2J2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBE2J2 Related Articles
UBE2J2 Related Research Area

UBE2J2 involved in several pathways and played different roles in them. We selected most pathways UBE2J2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	LILRA1;ERAP2;DNM1;CD300LG;RNF25;RNF6;IGLC2;DYNC1H1;CTSC
Antigen processing: Ubiquitination &amp	KLHL20;UBA5;UFL1;RNF14;FBXO44;GAN;KLHL21;UBR2;BLMH
Proteasome degradation	UBR2;NPEPPS;TRIM69;RNF41;PJA1;ATG7;RNF138;SH3RF1;TRAF7
Class I MHC mediated antigen processing &amp	RNF4;SPSB4;UBE2U;GAN;ASB10;ERAP1;CTSL2;UBE2E3;CD207
presentation	ATG7;DZIP3;ASB13;TRIM41;ERAP1;TRIM39;ARIH2;CYBA;RNF144B
Immune System	IRF9;MGC174152;NA;SPSB1;CASP4;PJA1;LRRFIP1;RAPGEF4;CLEC2H
Parkin-Ubiquitin Proteasomal System pathway	STUB1;RNF19A;SIAH2;HSPA14;UBE2J2;TUBA3E;TUBB7P;TUBA3D;HSPA7
Parkinsons disease	PRKACB;SDHD;COX7A1;UQCR10;ATP5F1;UBA1;SLC25A31;COX6A2;SDHA
Parkinsons Disease Pathway	ATXN2;SYT11;LRRK2;UBE2J2;PARK7
Protein processing in endoplasmic reticulum	DNAJB12;DNAJB1B;UBE2E1;HSP70;CAPN2;HSPBP1;DNAJC5G;MAP2K7;HSPA6

UBE2J2 has several biochemical functions, for example, ATP binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2J2 itself. We selected most functions UBE2J2 had, and list some proteins which have the same functions with UBE2J2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ATP5A1;LATS2;MYH8;UBE2F;KIF3B;SRPK2;PCXB;CARS;WEE2
ubiquitin conjugating enzyme activity	UBE2R2;UBE2S;UBE2V2;UBE2D4;UBE2QL1;UBE2V1;UBE2J2;UBE2E3;UBE2A
ubiquitin protein ligase activity	FBXL22;UBE3C;RNF152;PARK2;HECTD1;PDZD4;HERC2;UBE2C;C12orf51
ubiquitin protein ligase binding	TMEM189;RIPK1;PARK2;PRKAR1A;PRKACB;ARIH1;WFS1;TRIB1;UBE2B

UBE2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2J2.

PDE4DIP; FLJ10404; UBE1; ATP13A2

Lam, SY; Murphy, C; et al. The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:361-366(2014).

van den Boomen, DJH; Timms, RT; et al. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:11425-11430(2014).

E2 Ubiquitin/Ubl Conjugating Enzymes