Your Position: Home
Official Full Name
ubiquitin-conjugating enzyme E2K
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING;finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntingtons disease. Known functions for;this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis;in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the;endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different;isoforms have been identified for this gene.
UBE2K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein; huntingtin interacting protein 2; huntingtin-interacting protein 2; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 kDa; Lig; Hip2; Hypg; E2-25k; AW492011; D5Ertd601e