UBQLN1
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Official Full Name
ubiquilin 1
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Overview
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimers and Parkinsons disease. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
UBQLN1; ubiquilin 1; ubiquilin-1; DA41; DSK2; PLIC 1; XDRP1; hPLIC-1; protein linking IAP with cytoskeleton 1; UBQN; PLIC-1; FLJ90054;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- UBQLN1 Related Research Area
UBQLN1 involved in several pathways and played different roles in them. We selected most pathways UBQLN1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBQLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | LMAN2;SEC61AL2;BCAP31;DNAJB1;CAPN1;LMAN1;SEC23B;UBQLNL;HSPA1L |
UBQLN1 has several biochemical functions, for example, identical protein binding, kinase binding, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBQLN1 itself. We selected most functions UBQLN1 had, and list some proteins which have the same functions with UBQLN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | APPL1;MTSS1;NPR2;APAF1;GDF5;PCBD1;STIM1;PITX2;SYP |
| kinase binding | PARK2;BARD1;SNAI1;ATF5;CDC37;DLG3;DLG1;STRADA;TRIP6 |
| polyubiquitin binding | HDAC6;RAD23A;DNAJB2;UBQLN1;PSMD4;PSMD4A;RAD18;FAM175B;BRCC3 |
| protein binding | TCF7L1A;GBP2;JAKMIP2;OCRL;MAPKAPK5;Arid4b;ZNF785;CD86;FGF3 |
UBQLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBQLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBQLN1.
SERPINI2; HSPA13; UBQLN4; 3537
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