UBR2
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Official Full Name
Ubiquitin protein ligase E3 component n-recognin 2
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Overview
Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM] -
Synonyms
UBR2;Ubiquitin protein ligase E3 component n-recognin 2;Rabbit;Human;Rabbit Anti-Human UBR2 Polyclonal Antibody;Rabbit Anti-Human UBR2;Polyclonal Antibody;Rabbit Anti-Human UBR2 Antibody;Polyclonal;Rabbit Anti-Human UBR2 Polyclonal;Antibody;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2 Polyclonal;Anti-Human UBR2 Antibody;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2;Anti-UBR2;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2;Anti-Ubiquitin protein ligase E3 component n-recognin 2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | UBR2-3561H | Recombinant Human UBR2, GST-tagged | E.coli | GST | 1-347aa | |
| Human | UBR2-1876HCL | Recombinant Human UBR2 cell lysate | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
UBR2 involved in several pathways and played different roles in them. We selected most pathways UBR2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | SIGLEC6;RNF220;IGKC;ASB11;CTSO;PDPK1A;SEC23A;UBE2J2;HUWE1 |
| Antigen processing: Ubiquitination & | NPEPPS;ASB17;PJA1;TRIM41;ASB4;TPP2;SPSB1;HUWE1;ASB10 |
| Proteasome degradation | BLMH;ASB2;TRIM39;WSB1;FBXO44;TRIM69;ASB7;HUWE1;PJA1 |
| Class I MHC mediated antigen processing & | ASB13;ASB18;ASB2;LRR1;CTSS;UBE2V1;SEC61B;ERAP1;HUWE1 |
| presentation | STUB1;RNF144B;PJA1;RBCK1;FBXO44;CTSS;UBE2V2;UBE2L6;CD207 |
| Immune System | BTR06;AP1M2;KIF2B;DEFB119;GBP2;BAIAP2;AF251705;LGALS3;ABI1A |
UBR2 has several biochemical functions, for example, leucine binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR2 itself. We selected most functions UBR2 had, and list some proteins which have the same functions with UBR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| leucine binding | UBR1;UBR2;GLUD1;GLUD2 |
| ligase activity | HECTD1;UBE2NA;RNF5;TRIM27;CCNB1IP1;DTX3L;TMEM129;UBR2;PJA1 |
| protein binding | AUP1;TECPR2;EIF6;HIPK1;HIC1;COMMD1;ZNF230;UBE2N;PODXL2 |
| ubiquitin protein ligase activity | RNF181;CBL;ARIH1;HERC3;WWP1;TRIM59;PRPF19;MSL2B;TRIM2 |
| zinc ion binding | NR1H3;LHX2;BRPF1;PML;ZFAND5B;MAP3K7IP3;KMT2A;LHX1B;PRKCB |
UBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR2.
vif; Ttll7; UBXN7; MYC; NES; TIRAP; Dynlrb1; UBXN1; Naa11; SGOL1; MRPL50; FAF2; Cdc26; PARD6B; FAF1
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