UBR4
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Official Full Name
ubiquitin protein ligase E3 component n-recognin 4
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Overview
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. -
Synonyms
UBR4; ubiquitin protein ligase E3 component n-recognin 4; zinc finger, UBR1 type 1 , ZUBR1; E3 ubiquitin-protein ligase UBR4; KIAA0462; KIAA1307; RBAF600; 600 kDa retinoblastoma protein associated factor; 600 kDa retinoblastoma protein-associated factor; N-recognin-4; p600; Retinoblastoma associated factor 600 like protein; Retinoblastoma associated factor of 600 kDa; Retinoblastoma-associated factor 600; Retinoblastoma-associated factor of 600 kDa; Ubiquitin protein ligase E3 component n recognin 4; UBR4_HUMAN; Zinc finger UBR1 type protein 1; Zinc finger UBR1-type protein 1; Zinc finger, UBR1 type 1; ZUBR 1; ZUBR1; OTTHUMP00000002585; retinoblastoma-associated factor 600-like protein; RP5-1126H10.1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | UBR4-3562H | Recombinant Human UBR4, His-tagged | E.coli | His | C-term-349aa | |
| Human | UBR4-32H | Recombinant Human UBR4 protein, His-tagged | E.coli | His | Val124~Arg396 | |
| Human | UBR4-33H | Recombinant Human UBR4 protein, GST-tagged | E.coli | GST | 451-799 aa |
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| Human | UBR4-01H | Recombinant Human UBR4 Protein, GST-Tagged | Wheat Germ | GST |
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| Mouse | UBR4-17762M | Recombinant Mouse UBR4 Protein | Mammalian Cell | His |
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| Mouse | UBR4-9860M-B | Recombinant Mouse UBR4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | UBR4-9860M | Recombinant Mouse UBR4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- UBR4 Related Articles
UBR4 involved in several pathways and played different roles in them. We selected most pathways UBR4 participated on our site, such as Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | C3;RBL2;RBPJ;UBE3A;GTF2A2;GRB2;CCNE1;HIST1H4B;HIST1H2BL |
UBR4 has several biochemical functions, for example, calmodulin binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR4 itself. We selected most functions UBR4 had, and list some proteins which have the same functions with UBR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | RGS4;PPP3CA;CNN3B;RYR3;KCNN4;CAMK2G;PATE4;PNCK;ASPM |
| ligase activity | NEURL3;MARCH8;RNF133;UBE2G1B;MDM2;RNF187;RNF185;RAG1;TRIM32 |
| protein binding | HEMK1;C15orf57;CEP70;KIF13B;C3orf15;ACCS;IFI16;SETBP1;S100A9 |
| ubiquitin-protein transferase activity | WWP2;TRIM21;PARK2;HECTD3;ZER1;RNF130;TRIM33;UBE2D3;TRAF4A |
| zinc ion binding | BMI1;SRSF7B;MT1B;ANAPC11;PGLYRP2;MARCH2;ZRANB2;CA9;KLF7 |
UBR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR4.
E7; VCAM1; gag-pol; E7; E7; MCRS1; PRPF40A; SRGN; UBE2A; UBE2B; Smad6; Nsfl1c
- Q&As
- Reviews
Q&As (7)
Ask a questionAltered UBR4 activity is linked to various diseases, including neurodegenerative disorders and cancers.
UBR4 works with other ubiquitin-proteasome components, coordinating protein quality control.
UBR4, part of the ubiquitin-proteasome system, is involved in identifying and marking proteins for degradation.
Genetic mutations in UBR4 can disrupt protein degradation processes, affecting cell function.
It helps regulate protein turnover by tagging misfolded or damaged proteins for destruction.
Targeting UBR4 could offer therapeutic benefits in conditions characterized by protein misfolding and aggregation.
UBR4 plays a role in responding to cellular stress by managing the removal of aberrant proteins.
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