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UBTF

Official Full Name

upstream binding transcription factor, RNA polymerase I
Overview

The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor, SL1. UBF binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner (1). Experiments reveal that a cooperative interaction between UBF and SL1 leads to the formation of a new protein-DNA complex at the UCE and core elements which indicate that formation of the UBF-SL1 complex is vital for transcriptional activation by UBF (2). UBF contains six HMG box domains. The contribution of each HMG box motif to its function is different (3). Its believed that HMG motifs are the DNA-binding domains of UBF. Altering one of these boxes, as in the second form of UBF, may alter the functional characteristics of the transcription factor. Thus, the existence of different forms of UBF may have important ramifications for transcription by RNA polymerase I (4).
Synonyms

UBTF; upstream binding transcription factor, RNA polymerase I; nucleolar transcription factor 1; NOR 90; UBF; autoantigen NOR-90; 90-kDa nucleolus organizer region autoantigen; UBF1; UBF-1; NOR-90;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Zebrafish

Source

Baculovirus-Insect cells
E. coli
E.coli
HEK293
Mammalian Cell

Tag

C
His
His (Fc)
Avi
His|SUMO
SUMO
Myc|DDK
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UBTF-478H	Recombinant Human UBTF Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	UBTF-2505H	Recombinant Human UBTF Protein (1-670 aa), His-SUMO-tagged	E.coli	His/SUMO	1-670 aa	Inquiry
Human	UBTF-0514H	Recombinant Human UBTF Protein (Met1-Asn764), N-His-tagged	Baculovirus-Insect cells	N-His	Met1-Asn764	Inquiry
Human	UBTF-2406H	Recombinant Human UBTF protein, His-SUMO-tagged	E.coli	His-SUMO	1-764aa	Inquiry
Human	UBTF-2405H	Recombinant Human UBTF protein, His-tagged	E.coli	His	1-764aa	Inquiry
Human	UBTF-2672H	Recombinant Human UBTF protein(341-450 aa), C-His-tagged	E. coli	C-His	341-450 aa	Inquiry
Rat	UBTF-6414R	Recombinant Rat UBTF Protein	Mammalian Cell	His		Inquiry
Rat	UBTF-6070R	Recombinant Rat UBTF Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	UBTF-6070R-B	Recombinant Rat UBTF Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	UBTF-1408Z	Recombinant Zebrafish UBTF	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBTF Related Articles

UBTF involved in several pathways and played different roles in them. We selected most pathways UBTF participated on our site, such as Gene Expression, RNA Polymerase I Chain Elongation, RNA Polymerase I Promoter Clearance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	ZNF317;HNRPL;SESN3;NFIC;PUS7;ZNF157;NR1H3;ZNF776;ZNF490
RNA Polymerase I Chain Elongation	EFCAB11;CBX3;TAF1D;CBX3A;UBTF;TAF1A;TAF1B;TAF1C;CD3EAP
RNA Polymerase I Promoter Clearance	UBTF;EHMT2;TAF1A;MBD3B;CHD4A;MTA3;CD3EAP;EFCAB11;RRN3
RNA Polymerase I Promoter Escape	TAF1C;EFCAB11;UBTF;TAF1B;CD3EAP;TAF1D;RRN3;TAF1A
RNA Polymerase I Promoter Opening
RNA Polymerase I Transcription	MBD3B;PTRF;CHD4A;GATAD2AB;CD3EAP;UBTF;TAF1D;MBD3A;CBX3
RNA Polymerase I Transcription Initiation	MBD3B;RRN3;UBTF;MTA2;GATAD2AB;CHD4A;MBD3;CHD4;MTA1
RNA Polymerase I Transcription Termination	PTRFB;PTRF;UBTF

UBTF has several biochemical functions, for example, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBTF itself. We selected most functions UBTF had, and list some proteins which have the same functions with UBTF. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	SSRP1;TOX4;BAZ1B;ANKRD2;CAPNS2;NCAPD3;HOXD13;HDAC7A;HMGXB4A

UBTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBTF here. Most of them are supplied by our site. Hope this information will be useful for your research of UBTF.

Delmani, FA; Torreblanca, J; et al. Biological activity and redistribution of nucleolar proteins of two different cell lines treated with cis-dichloro-1,2-propylenediamine-N,N,N ',N '-tetraacetato ruthenium (III) (RAP). INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 52:579-588(2014).

Yang, XY; Jin, Y; et al. Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus. JOURNAL OF MOLECULAR ENDOCRINOLOGY 45:19-32(2010).