UCHL1
-
Official Full Name
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
-
Overview
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] -
Synonyms
UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- Mammalian Cell
- Mammalian cells
- Rabbit
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|S
- Myc
- DDK
- N/A
- N
- No tag
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- UCHL1 Related Articles
- UCHL1 Related Research Area
UCHL1 involved in several pathways and played different roles in them. We selected most pathways UCHL1 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | MT-ATP6;UBA1;UBE2L3;PINK1;NDUFB11;NDUFA3;SNCAIP;GPR37;UBB |
UCHL1 has several biochemical functions, for example, alpha-2A adrenergic receptor binding, cysteine-type endopeptidase activity, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL1 itself. We selected most functions UCHL1 had, and list some proteins which have the same functions with UCHL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-2A adrenergic receptor binding | ADRBK1;APLP1;UCHL1;ADRB1;ADRA2C |
| cysteine-type endopeptidase activity | FMNL3;CTSZ;CFLARA;USP2A;CASP3B;CTSLA;ESPL1;PSD;CASP1 |
| ligase activity | HACE1;HECW1B;TRIM32;GATB;SIAH1A;RING1;BIRC7;BTRC;UBE3A |
| omega peptidase activity | APEH;GGH;USP5;JOSD1;ATXN3;ATXN3L;JOSD2;USP13;UCHL1 |
| protein binding | GAPDHS;CCNL1;HSPA4L;SRSF2;KCP;FAM9B;COPRS;C12orf40;C9orf86 |
| ubiquitin binding | PER2;UCHL3;USP16;C36E6.2;IWS1;TNFAIP3;UCHL1;PARK2;IDE |
| ubiquitin protein ligase binding | SPG20;RPA2;UBE2KA;WASH;PML;RELA;TRIOBP;TRP53;UQCRC1 |
| ubiquitin-specific protease activity | YOD1;IWS1;USP19;OTUB1B;VCPIP1;USP43A;USP27X;USP24;USP51 |
UCHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL1.
COPS5; EGFR; TERF2IP; CDKN1B; NCAM1; EIF1B; KRT4; MCC; VHL; EIF6; KRT17; IKBKE; CCDC14; ATG5; USP21
- Q&As
- Reviews
Q&As (5)
Ask a questionEarly research suggests that changes in UCHL1 levels may be detected in the early stages of some neurodegenerative diseases, but more studies are needed for validation.
While UCHL1 is primarily associated with neurological functions, it also has roles in non-neuronal tissues, including certain types of cancer cells.
Challenges include the need for standardized assays, variations in UCHL1 levels among individuals, and the influence of other factors on its expression.
Yes, elevated or decreased levels of UCHL1 in cerebrospinal fluid or blood may serve as potential biomarkers for certain neurological disorders.
UCHL1 dysfunction has been implicated in conditions such as certain cancers and ischemic stroke.
Customer Reviews (3)
Write a reviewWhether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.
They provide comprehensive technical assistance and guidance throughout the entire research process.
Heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.
Ask a Question for All UCHL1 Products
Required fields are marked with *
My Review for All UCHL1 Products
Required fields are marked with *
