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UHRF2

Official Full Name

ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Overview

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.
Synonyms

UHRF2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin like with PHD and ring finger domains 2; E3 ubiquitin-protein ligase UHRF2; MGC33463; NIRF; Np95 like ring finger protein; RNF107; URF2; nuclear protein 97; R;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
SUMO
Myc
DDK
Myc|DDK
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UHRF2-10H	Recombinant Human UHRF2 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	UHRF2-507HCL	Recombinant Human UHRF2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	UHRF2-1103H	Recombinant Human UHRF2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	UHRF2-0417H	Recombinant Human UHRF2 Protein (T419-K648), His/SUMO tagged	E.coli	His/SUMO	T419-K648	Inquiry
Human	UHRF2-0416H	Recombinant Human UHRF2 Protein (T419-K648), Tag Free	E.coli	No tag	T419-K648	Inquiry
Mouse	UHRF2-17829M	Recombinant Mouse UHRF2 Protein	Mammalian Cell	His		Inquiry
Mouse	UHRF2-9900M-B	Recombinant Mouse UHRF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	UHRF2-9900M	Recombinant Mouse UHRF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UHRF2 Related Articles

UHRF2 involved in several pathways and played different roles in them. We selected most pathways UHRF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UHRF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

UHRF2 has several biochemical functions, for example, DNA binding, histone binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UHRF2 itself. We selected most functions UHRF2 had, and list some proteins which have the same functions with UHRF2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	BRIP1;KIAA0020;HIST1H2BM;ATXN1L;H2AFX;SPO11;ZFP775;HOXB10A;STAT1B
histone binding	HIST1H4N;USP16;ELP2;ZMYND11;AIRE;MCM2;L3MBTL2;SET;NAP1L2
ligase activity	UBE3C;HUWE1;TRIM38;ARIH2;SMURF2;RNF170;UBE3B;UBE2KB;RNF2
protein binding	SCOC;SIRT3;STX16;CSDE1;MEP1B;NPM2;MEF2C;TRAM1;RECQL
ubiquitin protein ligase activity	HECTD1;RNF146;TRIM24;UBE2S;HECW1B;RAD18;UBE2W;ITCH;RNF111
ubiquitin-protein transferase activity	HECW2;SHPRH;FBXO25;PAX6;TRIM56;RNF168;STUB1;UBR4;CDC34
zinc ion binding	DPP3;TCEA3;SHANK3;AGTPBP1;ZMYND11;ZMIZ2;SETMAR;MARCH2;ADAMTS15A

UHRF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHRF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHRF2.

CDK2; CCND1; CCNE1; RB1; TP53

Zhou, T; Xiong, J; et al. Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. MOLECULAR CELL 54:879-886(2014).

Lu, S; Yan, DW; et al. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. ONCOLOGY REPORTS 31:1802-1810(2014).