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ULK2

  • Official Full Name

    unc-51-like kinase 2 (C. elegans)

  • Overview

    This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms

    ULK2; unc-51-like kinase 2 (C. elegans); unc 51 (C. elegans) like kinase 2; serine/threonine-protein kinase ULK2; ATG1B; KIAA0623; Unc51.2; Serine/threonine protein kinase ULK2; ULK2_HUMAN; Unc 51 like kinase 2; Unc-51-like kinase 2; OTTHUMP00000065847; OTTHUMP00000065848;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ULK2-456H Active Recombinant Human ULK2 protein, GST-tagged Insect Cell GST
Human ULK2-255H Active Recombinant Human ULK2(1-306) Protein, N-GST,C-His-tagged Sf21 GST,His 1-306 aa
Human ULK2-1115H Recombinant Human Unc-51-Like Kinase 2 (C. elegans), GST-tagged Sf10 Insect Cell GST
Human ULK2-504HCL Recombinant Human ULK2 293 Cell Lysate HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ULK2 Related Articles

ULK2 involved in several pathways and played different roles in them. We selected most pathways ULK2 participated on our site, such as Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of autophagyULK3;ATG16L1;GABARAP;GABARAPA;IFNA3;IFNG;IFNPHI1;IFNA2;ULK2
mTOR signaling pathwayRRN3;VEGFAB;AKT3A;RRAGCA;RPS6;EIF4BB;RHEB;HIF1AB;ULK1

ULK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK2 itself. We selected most functions ULK2 had, and list some proteins which have the same functions with ULK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingHSPA4B;HARS;P2RX3;RLN1;TGFBR2;CSNK1DB;NME2;FGFR2;TBK1
protein bindingBBS1;RPL10A;ARGLU1;ABCG1;ARIH1;SAE1;OTUB2;CCDC106;KHDRBS2
protein serine/threonine kinase activityHIPK4;PRKACAA;HUNK;VRK1;ERN1;CDK12;PIM3;BMPR1AA;ACVR1L

ULK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK2.

RB1CC1; GABARAP; IRF1; GABARAPL2; MAP1LC3B; GABARAPL1; ZNF32; EEF1B2; NASP; POLA2; SETDB1; DIXDC1; LNX1; LUC7L2; PRKAB2

Huang, YH; Huang, XH; et al. Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death. FISH & SHELLFISH IMMUNOLOGY 43:241-248(2015).
Lee, S; Page-McCaw, P; et al. Kctd12 and Ulk2 Partner to Regulate Dendritogenesis and Behavior in the Habenular Nuclei (vol 9, e110280, 2014). PLOS ONE 10:-(2015).
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