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UNC13A

  • Official Full Name

    unc-13 homolog A

  • Overview

    This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play;important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be;associated with sporadic amyotrophic lateral sclerosis.
  • Synonyms

    UNC13A; unc-13 homolog A (C. elegans); protein unc-13 homolog A; KIAA1032; Munc13 1; Munc13-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UNC13A-4948H Recombinant Human UNC13A protein, His-tagged E.coli His 1-340aa
Mouse UNC13A-17840M Recombinant Mouse UNC13A Protein Mammalian Cell His
Mouse UNC13A-9909M Recombinant Mouse UNC13A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UNC13A-9909M-B Recombinant Mouse UNC13A Protein Pre-coupled Magnetic Beads HEK293
Rat UNC13A-6444R Recombinant Rat UNC13A Protein Mammalian Cell His
Rat UNC13A-6100R Recombinant Rat UNC13A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UNC13A-6100R-B Recombinant Rat UNC13A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UNC13A Related Articles
  • UNC13A Related Research Area

UNC13A involved in several pathways and played different roles in them. We selected most pathways UNC13A participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Synaptic vesicle cycleSTX1A;ATP6V1G1;ATP6V1B1;SLC17A7;ATP6V1E1;NAPA;RIMS1;RAB3A;SLC17A6

UNC13A has several biochemical functions, for example, SNARE binding, diacylglycerol binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13A itself. We selected most functions UNC13A had, and list some proteins which have the same functions with UNC13A. You can find most of the proteins on our site.

Function Related Protein
SNARE bindingMYO5A;TRIM9;SEC22C;TNFAIP2A;LRRK2;VAMP8;GOSR1;STX7;CCDC167
diacylglycerol bindingRASGRP1;RASGRP2;UNC13B;CDIPT;TRPC2;RASGRP3;UNC13C;RASGRP4;UNC13A
metal ion bindingB4GALT4;STAMBP;RARGB;GNAI2;CHSY3;CNOT7;FBXO30B;NPTX2;TRAF4A
protein N-terminus bindingNFE2;YWHAQ;CSNK2A1;RND2;RASSF1;TAF11;EIF5A;ALOX5AP;RELA
protein bindingNEUROG1;TUBB2A;KCND3;CRYGC;MICU1;ANG;SHOC2;MYL6B;NEFM
protein domain specific bindingST13;ARHGEF4;HIST1H4N;HIST1H4B;IGBP1;TUBA1A;CHMP2A;STMN3;DIXDC1
protein heterodimerization activityTCF3;NKX2-5;GTF2A2;HEXA;BHLHE40;HER5;HNF1B;TYRO3;MLXIPL
protein homodimerization activityDefa-rs7;TREX1;IDH1;CPNE1;SLC24A6;LRP4;TOX3;RABEP1;MYPOP
spectrin bindingKIF3A;GBP1;UNC13A;PDE6G;DYNC1I1;USH1C;MYO7A;EPB49;ADD2
syntaxin-1 bindingSNPH;RNF40;STXBP3A;VAMP3;SNAP25B;STXBP3;GOLSYN;UNC13A;SNAP25

UNC13A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13A.

Ywhab

Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).
BROSE, N; HOFMANN, K; et al. MAMMALIAN HOMOLOGS OF CAENORHABDITIS-ELEGANS UNC-13 GENE DEFINE NOVEL FAMILY OF C-2-DOMAIN PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY 270:25273-25280(1995).
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