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UPB1

Official Full Name

ureidopropionase, beta
Overview

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.
Synonyms

UPB1; ureidopropionase, beta; beta-ureidopropionase; BUP1; BUP-1; beta-alanine synthase; n-carbamoyl-beta-alanine amidohydrolase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
Myc
DDK
MYC
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UPB1-49H	Recombinant Human UPB1, His-tagged	E.coli	His		Inquiry
Human	UPB1-113H	Recombinant Human UPB1 Protein, His-tagged	E.coli	His		Inquiry
Human	UPB1-495HCL	Recombinant Human UPB1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	UPB1-967H	Recombinant Human UPB1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	UPB1-5906H	Recombinant Human UPB1 Protein (Trp121-Glu384), N-His tagged	E.coli	N-His	Trp121-Glu384	Inquiry
Mouse	Upb1-7919M	Recombinant Mouse Upb1 protein, His & T7-tagged	E.coli	His/T7	Leu154~Gly393 (Accession # Q8VC97)	Inquiry
Mouse	Upb1-225M	Recombinant Mouse Upb1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rat	UPB1-6455R	Recombinant Rat UPB1 Protein	Mammalian Cell	His		Inquiry
Rat	UPB1-6111R	Recombinant Rat UPB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	UPB1-6111R-B	Recombinant Rat UPB1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	UPB1-10017Z	Recombinant Zebrafish UPB1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UPB1 Related Articles

UPB1 involved in several pathways and played different roles in them. We selected most pathways UPB1 participated on our site, such as Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pyrimidine metabolism	UPB1;POLR3GLB;POLR1A;NME1-NME2;CANT1;NT5C2;TXNRD1;NT5C1AA;UPP1
beta-Alanine metabolism	CNDP2;HADHA;ALDH3A2;ALDH3B2;AOC2;ALDH9A1;CARNS1;GAD1B;HIBCH
Pantothenate and CoA biosynthesis	PANK1;PPCS;BCAT1;BCAT2;PPCDC;ENPP3;AASDHPPT;UPB1;DPYS
Drug metabolism - other enzymes	CES1;NAT;HPRT1;UMPS;GUSB;UPP1;UCK2;TPMT.1;UGT2A1
Metabolic pathways	MTMR6;PTGS2A;CYP2C39;RIMKLA;NDUFS3;GCDHA;CYP2P9;GALNT4;MCCC2

UPB1 has several biochemical functions, for example, beta-ureidopropionase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPB1 itself. We selected most functions UPB1 had, and list some proteins which have the same functions with UPB1. You can find most of the proteins on our site.

Function	Related Protein
beta-ureidopropionase activity
metal ion binding	CYBRD1;AMY1A;GIT2B;ARSE;ZNF562;ZNF32;EYA1;DRL;MTF1

UPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UPB1.

Lam, CW; Law, CY; et al. NMR-based urinalysis for rapid diagnosis of beta-ureidopropionase deficiency in a patient with Dravet syndrome. CLINICA CHIMICA ACTA 440:201-204(2015).

Shu, JB; Lv, XQ; et al. Genetic analysis of the UPB1 gene in two new Chinese families with beta-ureidopropionase deficiency and the carrier frequency of the mutation c. 977G > A in Northern China. CHILDS NERVOUS SYSTEM 30:2109-2114(2014).