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UPF3B

Official Full Name

UPF3 regulator of nonsense transcripts homolog B (yeast)
Overview

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms

UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast); MRX62; UPF3X; HUPF3B; MRXS14; RENT3B; regulator of nonsense transcripts 3B; hUpf3p-X; mental retardation, X-linked 62; nonsense mRNA reducing factor 3B; up-frameshift suppressor 3 homolog B; up-frameshift suppressor 3 homolog on chromosome X;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	UPF3B-31673TH	Recombinant Human UPF3B, His-tagged	E.coli	His	Inquiry
Human	UPF3B-2483H	Recombinant Human UPF3B Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	UPF3B-631H	Recombinant Human UPF3B Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Mouse	Upf3b-6846M	Recombinant Mouse Upf3b Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	UPF3B-5108R	Recombinant Rhesus monkey UPF3B Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	UPF3B-4921R	Recombinant Rhesus Macaque UPF3B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	UPF3B-4921R-B	Recombinant Rhesus Macaque UPF3B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	UPF3B-11191Z	Recombinant Zebrafish UPF3B	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
UPF3B Related Articles

UPF3B involved in several pathways and played different roles in them. We selected most pathways UPF3B participated on our site, such as RNA transport, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA transport	RANBP2;AAAS;XPO5;CYFIP2;EIF3EB;EIF4E2;UBE2I;NXT1;EIF1AXB
mRNA surveillance pathway	ETF1A;PABPC1B;PABPC1;BCL2L2-PABPN1;NXF2;SMG1;PPP2R3A;WDR33;MSI2

UPF3B has several biochemical functions, for example, actin binding, calmodulin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPF3B itself. We selected most functions UPF3B had, and list some proteins which have the same functions with UPF3B. You can find most of the proteins on our site.

Function	Related Protein
actin binding	PIP;ANTXR2A;KLHL4;MYO15;AFAP1;RP2;ABLIM2;MYBPC3;PXK
calmodulin binding	MARCKSL1A;CNN3A;MYO1F;MYO10;CAMKVB;INVS;PATE4;MYLK2;PCP4
protein binding	MYOG;CMTM2A;C1orf187;ZNF599;MGST3;RQCD1;CD93;DPM2;LRRC26

UPF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF3B.

RBM8A; UPF2; EIF4A3

Tarpey, PS; Raymond, FL; et al. Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. NATURE GENETICS 39:1127-1133(2007).