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USF1

  • Official Full Name

    upstream transcription factor 1

  • Overview

    This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    USF1; upstream transcription factor 1; upstream stimulatory factor 1; bHLHb11; MLTFI; UEF; major late transcription factor 1; class B basic helix-loop-helix protein 11; FCHL; MLTF; FCHL1; HYPLIP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USF1-1202H Active Recombinant Human Upstream Transcription Factor 1 E.coli N/A
Human USF1-1203H Active Recombinant Human Upstream Transcription Factor 1, GST-tagged E.coli GST
Human USF1-2447H Recombinant human USF1, His-tagged E.coli His
Human USF1-30031TH Recombinant Human USF1 E.coli N/A
Human USF1-479HCL Recombinant Human USF1 293 Cell Lysate HEK293 N/A
Human USF1-480HCL Recombinant Human USF1 293 Cell Lysate HEK293 N/A
Human USF1-5986H Recombinant Human USF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human USF1-5850H Recombinant Human USF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human USF1-3648H Recombinant Human USF1 protein, His-tagged E.coli His 3-310aa
Mouse Usf1-6859M Recombinant Mouse Usf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish USF1-10627Z Recombinant Zebrafish USF1 Mammalian Cell His
Chicken USF1-1743C Recombinant Chicken USF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • USF1 Related Articles

USF1 involved in several pathways and played different roles in them. We selected most pathways USF1 participated on our site, such as Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with USF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling mediated by p38-alpha and p38-betaUSF1;HBP1;GDI1;KRT8

USF1 has several biochemical functions, for example, bHLH transcription factor binding, double-stranded DNA binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USF1 itself. We selected most functions USF1 had, and list some proteins which have the same functions with USF1. You can find most of the proteins on our site.

Function Related Protein
bHLH transcription factor bindingPSMD9;IKZF4;EP300;SMAD3;SOX9;TCF12;TCF3;USF1;ISL1
double-stranded DNA bindingAPTX;YBX1;TEF;TDP1;TRP63;MTERF3;MRE11A;SATB1;XRCC5
enzyme bindingHSPA5;LDB1;GSTM3;EGFR;SNX12;GOLPH3;NCOA1;CYP1A2;HIF1A
histone deacetylase bindingSOD3;FOXP3;USF1;TRAF6;DHX36;PHB;XBP1;NR2C1;PRDM1
protein bindingTXNRD1;RNF138;TMEM106C;PGR;C14orf169;TGFBR2;MACROD1;TAF6L;ARHGEF4
protein heterodimerization activityPANX2;OSTA;ITGB1B;ADD2;MID1;SNX2;CLCN3;GUCY1A3;THRA
protein homodimerization activityNLRC4;BCL2A;CLN6;DROSHA;IKZF4;MCL1B;TBX18;IRAK3;NR6A1
protein kinase bindingSUFU;TEX14;PIWIL1;CHEK2;IKBKB;PRDX3;TRIB3;ZBTB4;MAP3K2
sequence-specific DNA bindingESRRA;PRRX1B;DLX3B;FOXQ1A;NR2F6B;GATA5;PTF1A;FOXJ3;POU3F3A
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingSOX17;CIR1;MEF2C;GATA5;CEBPA;MEIS1;RELA;ATF2;SFPI1

USF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of USF1.

PRKDC; USF2; KAT2B; PARP1; XRCC5; FOSL1

van Deursen, D; Jansen, H; et al. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. DIABETOLOGIA 51:2078-2087(2008).
Grassadonia, A; Tinari, N; et al. Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (mac-2BP) protein. ENDOCRINOLOGY 148:3507-3517(2007).
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