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USH1C

Official Full Name

Usher syndrome 1C (autosomal recessive, severe)
Overview

This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

USH1C; Usher syndrome 1C (autosomal recessive, severe); deafness, autosomal recessive 18 , DFNB18; harmonin; AIE 75; NY CO 37; NY CO 38; PDZ 73; PDZ73; antigen NY-CO-38/NY-CO-37; usher syndrome type-1C protein; renal carcinoma antigen NY-REN-3; autoimmune;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
Mammalian Cell

Tag

GST
His
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	USH1C-475H	Recombinant Human Usher Syndrome 1C, His-tagged	E.coli	His		Inquiry
Human	USH1C-3847H	Recombinant Human USH1C protein, His-tagged	E.coli	His	Met1-Phe552	$623 / 50 µg
Human	USH1C-3610H	Recombinant Human USH1C, GST-tagged	E.coli	GST	N-term-392aa	$319 / 25ug
Human	USH1C-29610TH	Recombinant Human USH1C, His-tagged	E.coli	His	533 amino acids	Inquiry
Human	USH1C-29611TH	Recombinant Human USH1C, His-tagged	E.coli	His		Inquiry
Human	USH1C-1892HCL	Recombinant Human USH1C cell lysate		N/A		Inquiry
Human	USH1C-4973H	Recombinant Human USH1C protein, His-SUMO-tagged	E.coli	His-SUMO	1-533aa	Inquiry
Zebrafish	USH1C-3685Z	Recombinant Zebrafish USH1C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
USH1C Related Articles

USH1C involved in several pathways and played different roles in them. We selected most pathways USH1C participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USH1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

USH1C has several biochemical functions, for example, actin filament binding, myosin tail binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USH1C itself. We selected most functions USH1C had, and list some proteins which have the same functions with USH1C. You can find most of the proteins on our site.

Function	Related Protein
actin filament binding	SHROOM3;SHROOM4;ANTXR1;ARPC1A;TRIOBPB;VCLA;MYH9;MACF1;SPTA1
myosin tail binding
protein binding	VEPH1;CNOT7;C1orf50;TUBB2B;C1QTNF3;HK2;DDAH2;RAD51D;GEM
spectrin binding	EPB49;MYO10;ADD2;DCTN2;GBP1;EPB41;PTPRN;UNC13A;STX4A

USH1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USH1C here. Most of them are supplied by our site. Hope this information will be useful for your research of USH1C.

RAC1; MIPOL1; CTNNAL1; USHBP1; QKI; pi3p; USH1G; CDHR2

Lampasona, V; Passerini, L; et al. Autoantibodies to Harmonin and Villin Are Diagnostic Markers in Children with IPEX Syndrome. PLOS ONE 8:-(2013).

Zhao, HY; Avenarius, MR; et al. Improved Biolistic Transfection of Hair Cells. PLOS ONE 7:-(2012).