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Official Full Name
UV radiation resistance associated gene
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
UVRAG; UV radiation resistance associated gene; UV radiation resistance associated; Uvrag1; Uvragl; AI648770; BB124205; 9530039D02Rik