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VAC14

  • Official Full Name

    Vac14 homolog (S. cerevisiae)

  • Overview

    The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with;fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a;trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the;PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14;functions as an activator of PIKFYVE (Sbrissa et al., 2007 (PubMed 17556371)).
  • Synonyms

    VAC14; Vac14 homolog (S. cerevisiae); Tax1 (human T cell leukemia virus type I) binding protein 2 , TAX1BP2; protein VAC14 homolog; ArPIKfyve; FLJ10305; FLJ36622; FLJ46582; MGC149815; MGC149816; OTTHUMP00000174908; Tax1 (human T cell leukemia virus type I) binding protein 1; Tax1 (human T cell leukemia virus type I) binding protein 2; Tax1 binding protein 2; Tax1-binding protein 2; TAX1BP2; TRX; VAC 14; Vac14 homolog; VAC14_HUMAN; Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1 (human T-cell leukemia virus type I) binding protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VAC14-29818TH Recombinant Human VAC14, His-tagged E.coli His
Human VAC14-1901HCL Recombinant Human VAC14 cell lysate N/A
Human VAC14-02H Recombinant Human VAC14 Protein (1-782), N-GST-tagged Wheat Germ N-GST 1-782
Human VAC14-03H Recombinant Human ULBP1 Protein (Gly26-Pro215), C-Fc-tagged Wheat Germ N-GST 714-782
Human VAC14-1514HFL Recombinant Full Length Human VAC14 Protein, C-Flag-tagged Mammalian cells Flag
Human VAC14-2331H Recombinant Human VAC14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VAC14-2331H-B Recombinant Human VAC14 Protein Pre-coupled Magnetic Beads HEK293
Mouse VAC14-17970M Recombinant Mouse VAC14 Protein Mammalian Cell His
Mouse VAC14-9988M-B Recombinant Mouse VAC14 Protein Pre-coupled Magnetic Beads HEK293
Mouse VAC14-9988M Recombinant Mouse VAC14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Vac14-6890M Recombinant Mouse Vac14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat VAC14-6490R Recombinant Rat VAC14 Protein Mammalian Cell His
Rat VAC14-6146R Recombinant Rat VAC14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VAC14-6146R-B Recombinant Rat VAC14 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VAC14-5139R Recombinant Rhesus monkey VAC14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque VAC14-4952R-B Recombinant Rhesus Macaque VAC14 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VAC14-4952R Recombinant Rhesus Macaque VAC14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish VAC14-1364Z Recombinant Zebrafish VAC14 Mammalian Cell His
Chicken VAC14-2278C Recombinant Chicken VAC14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

VAC14 involved in several pathways and played different roles in them. We selected most pathways VAC14 participated on our site, such as HTLV-I infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAC14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HTLV-I infectionRAN;WNT9B;PRKACA;MAP2K4;APC;TLN1;CDC26;IL2RG;WNT11
Viral carcinogenesisPSMC1;YWHAB;HIST1H4A;PRKACG;TRP53;MAPK1;ACTN4;TRAF3;HIST1H4L

VAC14 has several biochemical functions, for example, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAC14 itself. We selected most functions VAC14 had, and list some proteins which have the same functions with VAC14. You can find most of the proteins on our site.

Function Related Protein
protein bindingMCCC1;ELMOD3;KIAA0649;LAT;YWHAE;C7orf31;RABGAP1L;PPP2R5C;NPY2R
receptor activityCD226;RTN4RL1;NLGN4Y;XPR1;RET;ANPEP;TNFRSF11B;ITGAX;PAQR9

VAC14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAC14 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAC14.

PIKFYVE; NOS1; PPP2CA; CDRT4; 9659

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