VAV2
-
Official Full Name
vav 2 guanine nucleotide exchange factor
-
Overview
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and -
Synonyms
VAV2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; guanine nucleotide exchange factor VAV2; VAV-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- VAV2 Related Articles
- VAV2 Related Signal Pathway
VAV2 involved in several pathways and played different roles in them. We selected most pathways VAV2 participated on our site, such as Rap signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | SIPA1L1;ANGPT1;LAT;ITGB1;PLCB3;KRIT1;PFN1;PIK3CD;INS2 |
| cAMP signaling pathway | CAMK2A;HCAR2;MAPK10;ARAP3;PIK3R1;HTR1E;ROCK2;HTR1B;CALML3 |
| Chemokine signaling pathway | NFKBIB;GNAI1;CCL21;PRKACB;BCAR1;RAP1A;WASL;CXCL6;CCL24 |
| Focal adhesion | AKT2;CCND2A;EGFRA;PGF;PTEN;PXNA;RHOAA;COL6A1;PIK3R3A |
| Natural killer cell mediated cytotoxicity | FCGR4;PPP3R2;PAK1;IFNA10;RAC3;KLRC3;IFNA1;TNFSF10;H60a |
| T cell receptor signaling pathway | PAK6;CD8B;MUC1;PAK3;PAK7;RELA;OXSR1A;CD3E; CD3D;MAP2K2 |
| B cell receptor signaling pathway | PDPK1A;BLNK;IFITM1;NRAS;ARPC1B;GSK3B;DOK1B;NFATC1;GSK3AB |
| Fc epsilon RI signaling pathway | HRAS;MAP2K2;MAP2K1;PIK3R1;PIK3CD;IL13;PIK3CG;MS4A2;RAC3 |
| Fc gamma R-mediated phagocytosis | VAV3;PRKCD;MARCKS;LIMK2;MAPK3;PRKCB;PLA2G4A;PLA2G6;RAF1 |
| Leukocyte transendothelial migration | CYBB;CLDN17;ARHGAP35;MMP9;CLDN4;ITGAM;ICAM1;ROCK1;CLDN22 |
| Regulation of actin cytoskeleton | ITGA5;GSN;Itgam&Itgb2;RDX;MAP2K1;FGF3;CDC42L2;FGD1;ITGAE |
| Proteoglycans in cancer | RRAS;ARAF;TLR2;FGF2;HSPB2;Fzd4;ITGB5;WNT2B;PTK2 |
VAV2 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV2 itself. We selected most functions VAV2 had, and list some proteins which have the same functions with VAV2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | FGD;ARHGEF25;ARHGEF39;PREX1;ITSN1;TRIO;ARHGEF9;TIAM2;ABR |
| epidermal growth factor receptor binding | AREG;GRB2;MS4A1;Fert2;HBEGFB;CBLC;FER;LINGO1B;FAM83B |
| guanyl-nucleotide exchange factor activity | NET1;FAM116B;VAV3;TRIO;ARHGEF7;KNDC1;FFAR1;DOCK4;RAPGEF6 |
| metal ion binding | ZFP191;B4GALT5;DGCR8;PDLIM3A;ZNF500;GNA11;ATP8B3;TCN2;PVALB7 |
| protein binding | GJD3;CDKN1C;ALKBH4;ACAN;HIPK4;CHRAC1;CHORDC1;GPBP1;ANKS4B |
VAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV2.
SH3BP2; TTN; TOM1L1; ERBB2; MET; AR; ERBB3; GAB1; ABI1; Mbp; PRLR
- Q&As
- Reviews
Ask a Question for All VAV2 Products
Required fields are marked with *
My Review for All VAV2 Products
Required fields are marked with *
