VDAC1
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Official Full Name
voltage-dependent anion channel 1
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Overview
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] -
Synonyms
VDAC1; voltage-dependent anion channel 1; PORIN; VDAC-1; voltage-dependent anion-selective channel protein 1; porin 31HL; porin 31HM; plasmalemmal porin; outer mitochondrial membrane protein porin 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- VDAC1 Related Articles
VDAC1 involved in several pathways and played different roles in them. We selected most pathways VDAC1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | GNA11B;ITPKB;PPP3R1;RYR1B;GNAL;PLCB1;P2RX3A;CALM1B;TNNC1B |
| cGMP-PKG signaling pathway | PPP1R12A;PPIF;ATP1B1;MAPK1;INS1;PRKCE;AKT2;PIK3CA;PRKG2 |
| Parkinsons disease | NDUFA7;UBA1;UBE2J1;GNAI3;NDUFB2;DRD1A;COX7A2L;APAF1;NDUFS8 |
| Huntingtons disease | NDUFS2;POLR2L;TFAM;SOD2;NDUFB8;NDUFA11;DNAHC8;DNAH6;COX6A1 |
| Influenza A | GSK3B;RAE1;HLA-DPA1;IFNG;TLR7;PIK3CA;PIK3R5;RSAD2;IFNA2 |
| HTLV-I infection | PDGFRA;ANAPC5;HLA-DRB3;SLC25A5;CCND1;IL6;TSPO;CDC16;PIK3R3 |
VDAC1 has several biochemical functions, for example, ion channel binding, porin activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC1 itself. We selected most functions VDAC1 had, and list some proteins which have the same functions with VDAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | PDE4B;FGF12;RANGRF;VDAC1;FKBP1B;CIB1;DIAPH1;KCNJ11;PIRT |
| porin activity | AQP9;VDAC3;TOMM40L;VDAC1;TOMM40;VDAC2 |
| protein binding | HBD;LGALSL;PDCL3;SF3B3;TPSAB1;BTN3A1;MAGEE1;DYM;ZFC3H1 |
| protein complex binding | IGBP1;GRIN2A;FGFR1;CAV3;KRT8;PPARA;MYC;TULP2;SHANK1 |
| protein kinase binding | PTPRC;CCNYL1;DNAJC3;SOCS1;CCNK;MAPK4;CCNA2;NCS1;PTPRJ |
| voltage-gated anion channel activity | GPR89;VDAC2;SLC17A3;VDAC1;VDAC3 |
VDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC1.
ATF2; Bax; BAK1; VCAM1; env; HSPA9; ITPR1; cholesterol; nadh
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