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VDR

  • Official Full Name

    vitamin D (1,25- dihydroxyvitamin D3) receptor

  • Overview

    This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
  • Synonyms

    VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; NR1I1; vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; vitamin D nuclear receptor variant 1; nuclear receptor subfamily 1 group I member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • HIS
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VDR-2516H Active Recombinant Human Vitamin D (1,25- dihydroxyvitamin D3) Receptor Insect Cell N/A
Human VDR-1204H Active Recombinant Human vitamin D receptor E.coli N/A
Human VDR-3659H Recombinant Human VDR, His-tagged E.coli His 128-427aa
Human VDR-1210H Recombinant Human VDR, His tagged Insect Cell His
Human VDR-31130TH Recombinant Human VDR N/A
Human VDR-200H Recombinant Human VDR protein, T7/His-tagged E.coli T7/His
Human VDR-2560H Recombinant Human VDR, His-tagged Insect Cell HIS
Human VDR-118H Recombinant Human VDR, GST-tagged Sf9 Insect Cell GST
Human VDR-562H Recombinant Human VDR protein, His-tagged E.coli His Met272~Ser427
Human VDR-462HCL Recombinant Human VDR cell lysate Insect Cell N/A
Human VDR-4781H Recombinant Human VDR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VDR-101H Recombinant Human VDR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human VDR-6553H Recombinant Human VDR Protein (Met272-Ser427), N-His tagged E.coli N-His Met272-Ser427
Mouse Vdr-7422M Recombinant Mouse Vdr, His tagged Insect Cell His
Mouse Vdr-2670M Recombinant Mouse Vdr protein, His & T7-tagged E.coli His/T7 Ile266~Ser422 (Accession # P48281)
Mouse VDR-001MCL Recombinant Mouse VDR cell lysate Insect Cell N/A
Mouse Vdr-6914M Recombinant Mouse Vdr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat VDR-6513R Recombinant Rat VDR Protein Mammalian Cell His
Rat VDR-6169R Recombinant Rat VDR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VDR-6169R-B Recombinant Rat VDR Protein Pre-coupled Magnetic Beads HEK293
Chicken VDR-6655C Recombinant Chicken VDR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VDR Related Articles
  • VDR Related Research Area

VDR involved in several pathways and played different roles in them. We selected most pathways VDR participated on our site, such as Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Endocrine and other factor-regulated calcium reabsorptionKLK1B3;DNM2;KLK1B22;ATP1A1;ESR1;PLCB1;PRKCA;DNM3;TRPV5
Mineral absorptionTRPV6;MT1M;SLC26A3;Trf;ATP1A4;HEPH;SLC9A3;MT2;SLC26A6
TuberculosisHSPA9;PMAP-36;STAT1;CASP10;IFNB1;IL1B;MYD88;TGFB3;SPHK1

VDR has several biochemical functions, for example, DNA binding, calcitriol binding, calcitriol receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VDR itself. We selected most functions VDR had, and list some proteins which have the same functions with VDR. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNHEJ1;NFAT5A;HELT;ETS2;SRFA;HER7;DNA2;ZNF445;EOMESB
calcitriol bindingVDR;VDRA
calcitriol receptor activityVDR;VDRB;VDRA
lithocholic acid bindingVDRA;VDR
lithocholic acid receptor activity
protein bindingTXK;RPL30;FBXO46;PACSIN1;RABIF;GPR77;UBE2A;PPFIA2;NEK11
retinoid X receptor bindingFUS;NCOR1;RARB;NR1H2;PPARG;NR4A2;VDR;NR0B2;NRIP1
sequence-specific DNA bindingCAMTA2;FOXK2;PRRX1B;NR2F5;FOXO1;TBX5;FEV;UNCX4.1;HOXB3A
steroid hormone receptor activityNR2C1;RARAB;NR6A1A;NR2E3;VDRB;RXRGA;ESRRB;ESRRGB;ESRRG
contributes_to transcription factor activity, sequence-specific DNA bindingTAF12;SMAD2;RXRA;SMAD3;VDRA;TAF7;VDRB;SOX19A;TRIM28
contributes_to vitamin D response element bindingVDRB;VDR;RXRA;VDRA
zinc ion bindingSRSF7;RNF149;THRAA;SAMHD1;MT3;TOP3A;RNF121;IDE;RPS29

VDR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDR here. Most of them are supplied by our site. Hope this information will be useful for your research of VDR.

SNW1; RXRA; EP300; TP53; co1a1_human_vdr-site_dna-probe; PTPN3

Bizzaro, G; Shoenfeld, Y; et al. Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. IMMUNOLOGIC RESEARCH 61:46-52(2015).
Bizzaro, G; Shoenfeld, Y; et al. Vitamin D and thyroid autoimmune diseases: the known and the obscure. IMMUNOLOGIC RESEARCH 61:107-109(2015).
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