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VNN1

Official Full Name

vanin 1
Overview

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
Synonyms

VNN1; vanin 1; pantetheinase; Tiff66; HDLCQ8; High density lipoprotein cholesterol level quantitative trait locus 8, included; Pantetheine hydrolase; V-1; Vanin-1; Vannin 1; Vascular non inflammatory molecule 1; Vascular non-inflammatory molecule 1; VNN 1; VNN1_HUMAN;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Cattle
Chicken
Human
Mouse
Rat

Source

CHO
E.coli
HEK293
Human Cell
Mammalian Cell

Tag

C
His
Fc
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	VNN1-1084H	Active Recombinant Human VNN1 Protein, His-tagged	CHO	His	Gln22-Ser490	Inquiry
Human	VNN1-3668H	Recombinant Human VNN1, His-tagged	E.coli	His	302-513aa	$319 / 25ug
Human	VNN1-3229H	Active Recombinant Human VNN1 protein, His-tagged	HEK293	His	Met1-Ser490	$623 / 20 µg
Human	VNN1-7931H	Recombinant Human VNN1 protein, His-tagged	E.coli	His	Leu36~Leu223 (Accession # O95497)	Inquiry
Human	VNN1-2442HCL	Recombinant Human VNN1 cell lysate	Human Cell	N/A		Inquiry
Human	VNN1-572H	Recombinant Human VNN1 Protein, His-tagged	E.coli	N-His	Gln22-Gly491	Inquiry
Human	VNN1-6674H	Recombinant Human VNN1 Protein (Ser302-Trp513), N-His tagged	E.coli	N-His	Ser302-Trp513	Inquiry
Human	VNN1-2671H	Active Recombinant Human VNN1 protein, His-tagged	HEK293	His	Gln22-Ser490	Inquiry
Mouse	Vnn1-2560M	Recombinant Mouse Vnn1 protein(Met1-Ser487), His-tagged	HEK293	C-His	Met1-Ser487	Inquiry
Mouse	Vnn1-7932M	Recombinant Mouse Vnn1 protein, His-tagged	E.coli	His	Val390~Ile503 (Accession # Q9Z0K8)	Inquiry
Mouse	VNN1-933M	Recombinant Mouse VNN1 Protein, Fc-tagged	HEK293	Fc		Inquiry
Mouse	VNN1-1583MCL	Recombinant Mouse VNN1 cell lysate	Human Cell	N/A		Inquiry
Rat	Vnn1-7933R	Recombinant Rat Vnn1 protein, His & T7-tagged	E.coli	His/T7	Ser22~Pro328 (Accession # Q4KLZ0)	Inquiry
Cattle	VNN1-7930C	Recombinant Cattle VNN1 protein, His & T7-tagged	E.coli	His/T7	Leu216~Gly469 (Accession # Q58CQ9)	Inquiry
Chicken	VNN1-3349C	Recombinant Chicken VNN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
VNN1 Related Research Area

VNN1 involved in several pathways and played different roles in them. We selected most pathways VNN1 participated on our site, such as Pantothenate and CoA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VNN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pantothenate and CoA biosynthesis	COASY;PPCS;BCAT2;DPYS;ENPP1;PANK4;PPCDC;PANK1;AASDHPPT

VNN1 has several biochemical functions, for example, GPI anchor binding, pantetheine hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VNN1 itself. We selected most functions VNN1 had, and list some proteins which have the same functions with VNN1. You can find most of the proteins on our site.

Function	Related Protein
GPI anchor binding	CEACAM5;MPPE1;NIPAL1;DPEP1;THY1;VNN1
pantetheine hydrolase activity	VNN1;VNN3;VNN2

VNN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VNN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VNN1.

T Cell Migration