VPS24

Official Full Name

Vacuolar Protein Sorting 24 homolog (S. cerevisiae)

Background

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene.

Synonyms

VPS24; vacuolar protein sorting 24 homolog (S. cerevisiae); NEDF; CHMP3; CGI-149; FLJ38114; charged multivesicular body protein 3; 25.1 protein; OTTHUMP00000203324; OTTHUMP00000203325; OTT- HUMP00000203326; CHMP family, member 3; chro- matin-modifying protein 3; neuroendocrine differentiation factor; vacuolar protein sorting-associated protein 24; hVps24; vacuolar protein sorting 24 (yeast); Neur- oendocrine differentiation factor; Vacuolar protein sorting-associated protein 24