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WARS

  • Official Full Name

    tryptophanyl-tRNA synthetase

  • Overview

    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms

    WARS; tryptophanyl-tRNA synthetase; IFI53; tryptophanyl-tRNA synthetase, cytoplasmic; IFP53; tryptophan tRNA ligase 1; cytoplasmic; Gamma 2; Gamma2; hWRS; IFI 53; IFP 53; Interferon induced protein 53; Interferon-induced protein 53; SYWC_HUMAN; T2-TrpRS; TrpRS; Tryptophan tRNA ligase 1 cytoplasmic; Tryptophan tRNA ligase; Tryptophan--tRNA ligase; Tryptophanyl tRNA synthetase; Tryptophanyl tRNA synthetase cytoplasmic; WARS protein; WRS; OTTHUMP00000246493; OTTHUMP00000246494; OTTHUMP00000246495; OTTHUMP00000246496; OTTHUMP00000246497; OTTHUMP00000246498; tryptophan tRNA ligase 1, cytoplasmic; GAMMA-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|Myc
  • His|T7
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WARS-3698H Recombinant Human WARS, GST-tagged E.coli GST 1-368aa
Human WARS-283H Recombinant Human WARS, His tagged Insect Cell His
Human WARS-30746TH Recombinant Human WARS, His-tagged E.coli His 471 amino acids
Human WARS-30747TH Recombinant Human WARS, His-tagged E.coli His 471 amino acids
Human WARS-164H Recombinant Human WARS Protein, His-tagged E.coli His
Human WARS-165H Recombinant Human WARS Protein, His-tagged E.coli His
Human WARS-370HCL Recombinant Human WARS 293 Cell Lysate HEK293 N/A
Human WARS-001HCL Recombinant Human WARS cell lysate Insect Cell N/A
Human WARS-3759H Recombinant Human WARS protein, His&Myc-tagged E.coli His&Myc 2-471aa
Human WARS-3046H Recombinant Human WARS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WARS-2410H Recombinant Human WARS Protein (2-471 aa), His-Myc-tagged Yeast His/Myc 2-471 aa
Human WARS-6570H Recombinant Human WARS Protein (Phe247-Lys458), His tagged E.coli His Phe247-Lys458
Mouse WARS-18424M Recombinant Mouse WARS Protein Mammalian Cell His
Mouse Wars-1739M Recombinant Mouse Wars protein, His & T7-tagged E.coli His/T7 Ser29~Leu195 (Accession # P32921)
Mouse WARS-10104M Recombinant Mouse WARS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Wars-6961M Recombinant Mouse Wars Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse WARS-10104M-B Recombinant Mouse WARS Protein Pre-coupled Magnetic Beads HEK293
Rat Wars-1740R Recombinant Rat Wars protein, His & T7-tagged E.coli His/T7 Ile140~Leu347 (Accession # Q6P7B0)
Zebrafish WARS-11034Z Recombinant Zebrafish WARS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WARS Related Articles

WARS involved in several pathways and played different roles in them. We selected most pathways WARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with WARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisFARS2;VARS;SARS;MARS;PSTK;AARS2;DARS2;PARS2;LARS

WARS has several biochemical functions, for example, ATP binding, protein binding, tryptophan-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WARS itself. We selected most functions WARS had, and list some proteins which have the same functions with WARS. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX50;KIF9;CDC42BPB;PHKG1;ABCG2D;SHPK;PRKCHB;PHKG1A;CAMKVB
protein bindingMASP1;C19orf25;SPRY4;TNFAIP3;OGG1;HMGB1;LZTS2;SH3BP1;SPON1
tryptophan-tRNA ligase activityWARS2;WARS

WARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WARS here. Most of them are supplied by our site. Hope this information will be useful for your research of WARS.

TERF1; DDA1; MDH2; DOC-1R; DCAF13; DNMT3B

Sancak, A; Favrot, C; et al. Antibody titres against canine papillomavirus 1 peak around clinical regression in naturally occurring oral papillomatosis. VETERINARY DERMATOLOGY 26:57-+(2015).
Whitby, T; Schroeder, D; et al. Modifications in Integrin Expression and Extracellular Matrix Composition in Children with Biliary Atresia. KLINISCHE PADIATRIE 227:15-22(2015).
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