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WBSCR22

Official Full Name

Williams Beuren syndrome chromosome region 22
Overview

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found.
Synonyms

WBSCR22; Williams Beuren syndrome chromosome region 22; uncharacterized methyltransferase WBSCR22; MGC2022; MGC5140; MGC19709; PP3381; WBMT; HASJ4442; HUSSY 3; HUSSY3; WBS22_HUMAN; Williams Beuren candidate region putative methyltransferase; Williams Beuren syndrome chromosome region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren candidate region putative methyltransferase; HUSSY-3;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	WBSCR22-362HCL	Recombinant Human WBSCR22 293 Cell Lysate	HEK293	N/A	Inquiry
Rhesus Macaque	WBSCR22-5191R	Recombinant Rhesus monkey WBSCR22 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	WBSCR22-5004R	Recombinant Rhesus Macaque WBSCR22 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	WBSCR22-5004R-B	Recombinant Rhesus Macaque WBSCR22 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	WBSCR22-5264Z	Recombinant Zebrafish WBSCR22	Mammalian Cell	His	Inquiry
Chicken	WBSCR22-3385C	Recombinant Chicken WBSCR22	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
WBSCR22 Related Articles

WBSCR22 involved in several pathways and played different roles in them. We selected most pathways WBSCR22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WBSCR22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

WBSCR22 has several biochemical functions, for example, methyltransferase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WBSCR22 itself. We selected most functions WBSCR22 had, and list some proteins which have the same functions with WBSCR22. You can find most of the proteins on our site.

Function	Related Protein
methyltransferase activity	SETDB1B;NSUN5;PRDM10;THUMPD2;ALDH1L1;FAM86C;METTL4;EHMT1;SKINT8
poly(A) RNA binding	PURA;NXF3;GANAB;HMGB3;MYO5A;LUC7L2;JUN;FARSA;SF3A3

WBSCR22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WBSCR22 here. Most of them are supplied by our site. Hope this information will be useful for your research of WBSCR22.

FOS; PRKAB1; OAS1; VCP; PKN1; gltX; ssrna_ag; NPM1; Rpl35

Verges, L; Molina, O; et al. Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers. MOLECULAR CYTOGENETICS 7:-(2014).

Gimelli, S; Chrast, J; et al. A t(7;12) Balanced Translocation With Breakpoints Overlapping Those of the Williams-Beuren and 12q14 Microdeletion Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:1285-1294(2010).