WEE1
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Official Full Name
WEE1 homolog
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Overview
Entry of all eukaryotic cells into mitosis is regulated by activation of cdc2 kinase. The critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Thr14 (1,2). Phosphorylation at Tyr15 and Th -
Synonyms
WEE1; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase; WEE1+ homolog; WEE1A; WEE1hu; FLJ16446; DKFZp686I18166;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf21
- Flag
- GST
- GST,His
- GST|His
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- FLAG
- 6×His
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- WEE1 Related Articles
- WEE1 Related Research Area
WEE1 involved in several pathways and played different roles in them. We selected most pathways WEE1 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with WEE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | MPEG1;CETN2;CDC6;FZR1;CDK7;CLSPN;CEP152;GORASP2;ENSA |
WEE1 has several biochemical functions, for example, ATP binding, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WEE1 itself. We selected most functions WEE1 had, and list some proteins which have the same functions with WEE1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | AGK;WNK1;UBE2O;DNAJA2L;MAT2A;TARS;ABCA4;PSTK;EPHA4A |
magnesium ion binding | ARF1;TDP2B;PKLR;GEM;IDH3B;FDXACB1;RPS6KA4;PKM2;PPM1BB |
non-membrane spanning protein tyrosine kinase activity | LCK;ABL2;PKDCC;FES;FYNB;FGR;BLK;STYK1;FYN |
protein binding | FYN;ASH2L;POLR1A;GABPB2;TACSTD2;YY1;BRD4;CNO;NANOS3 |
protein tyrosine kinase activity | CSF1RA;DYRK2;MAP2K1;KDR;FGFR3;EPHB4A;KITA;MAP2K5;IGF1R |
WEE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WEE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WEE1.
YWHAB; FBXW11; YWHAZ; BTRC; N/A; PLK1; Cdk1; SFN; YWHAG; NEK6; czc8004
- Q&As
- Reviews
Q&As (7)
Ask a questionIt plays a role in DNA damage response by delaying cell cycle progression to allow DNA repair.
Altered WEE1 activity is associated with the progression of various cancers.
Targeting WEE1 in cancer therapy could exploit its role in cell cycle regulation to inhibit tumor growth.
Genetic mutations in WEE1 can lead to uncontrolled cell division and genomic instability.
WEE1 is critical in checkpoint regulation, ensuring cells do not divide with damaged DNA.
WEE1 works in conjunction with other cell cycle proteins to regulate the timing of cell division.
WEE1 is a kinase that inhibits cell cycle progression, particularly at the G2/M checkpoint.
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