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WEE1

  • Official Full Name

    WEE1 homolog

  • Overview

    Entry of all eukaryotic cells into mitosis is regulated by activation of cdc2 kinase. The critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Thr14 (1,2). Phosphorylation at Tyr15 and Th
  • Synonyms

    WEE1; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase; WEE1+ homolog; WEE1A; WEE1hu; FLJ16446; DKFZp686I18166;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Flag
  • GST
  • GST,His
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • FLAG
  • 6×His
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WEE1-257H Active Recombinant Human WEE1(214-end) Protein, N-GST,C-His-tagged Sf21 GST,His 214-end
Human WEE1-15H Active Recombinant Human WEE1 Protein (Q36-Y432), N-GST-6×His tagged Insect Cell N-GST-6×His Q36-Y432
Human WEE1-3726H Recombinant Human WEE1, GST-tagged E.coli GST 297-646aa
Human WEE1-36H Recombinant Human WEE1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human WEE1-707H Recombinant Human WEE1 Protein, GST-HIS6-tagged Insect cell GST/His
Human WEE1-1930HCL Recombinant Human WEE1 cell lysate N/A
Human WEE1-0059H Recombinant Human WEE1 Protein (M291-K575), Tag Free Insect Cell No tag M291-K575
Human WEE1-001H Recombinant Human WEE1 Protein, GST-tagged Insect Cell GST
Human WEE1-35H Recombinant Human WEE1 Protein (247-end), N-GST tagged E.coli GST 247-end
Human WEE1-14H Recombinant Human WEE1 Protein (215-646, end), N-FLAG tagged Insect Cell N-FLAG 215-646
Human WEE1-8814HFL Recombinant Full Length Human WEE1 protein, Flag-tagged Mamanlian cells Flag
Human WEE1-6052H Recombinant Human WEE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WEE1-0060H Recombinant Human WEE1 Protein (M291-K575), His tagged Insect Cell His M291-K575
Human WEE129162H Recombinant Human WEE1 (291-575) Protein
Mouse WEE1-18521M Recombinant Mouse WEE1 Protein Mammalian Cell His
Mouse WEE1-10160M Recombinant Mouse WEE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Wee1-6992M Recombinant Mouse Wee1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse WEE1-10160M-B Recombinant Mouse WEE1 Protein Pre-coupled Magnetic Beads HEK293
Rat WEE1-6584R Recombinant Rat WEE1 Protein Mammalian Cell His
Rat Wee1-32R Recombinant Rat Wee1 protein, GST-tagged, active E.coli GST
Rat WEE1-6240R Recombinant Rat WEE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat WEE1-6240R-B Recombinant Rat WEE1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish WEE1-1445Z Recombinant Zebrafish WEE1 Mammalian Cell His
Chicken WEE1-2848C Recombinant Chicken WEE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WEE1 Related Articles
  • WEE1 Related Research Area

WEE1 involved in several pathways and played different roles in them. We selected most pathways WEE1 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with WEE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleMPEG1;CETN2;CDC6;FZR1;CDK7;CLSPN;CEP152;GORASP2;ENSA

WEE1 has several biochemical functions, for example, ATP binding, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WEE1 itself. We selected most functions WEE1 had, and list some proteins which have the same functions with WEE1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAGK;WNK1;UBE2O;DNAJA2L;MAT2A;TARS;ABCA4;PSTK;EPHA4A
magnesium ion bindingARF1;TDP2B;PKLR;GEM;IDH3B;FDXACB1;RPS6KA4;PKM2;PPM1BB
non-membrane spanning protein tyrosine kinase activityLCK;ABL2;PKDCC;FES;FYNB;FGR;BLK;STYK1;FYN
protein bindingFYN;ASH2L;POLR1A;GABPB2;TACSTD2;YY1;BRD4;CNO;NANOS3
protein tyrosine kinase activityCSF1RA;DYRK2;MAP2K1;KDR;FGFR3;EPHB4A;KITA;MAP2K5;IGF1R

WEE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WEE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WEE1.

YWHAB; FBXW11; YWHAZ; BTRC; N/A; PLK1; Cdk1; SFN; YWHAG; NEK6; czc8004

Schmid, BC; Oehler, MK; et al. New perspectives in ovarian cancer treatment. MATURITAS 77:128-136(2014).
Lehmann, BD; Pietenpol, JA; et al. Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. JOURNAL OF PATHOLOGY 232:142-150(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does WEE1 contribute to DNA damage response? 02/19/2023

It plays a role in DNA damage response by delaying cell cycle progression to allow DNA repair.

What is the impact of altered WEE1 activity on cancer development? 09/15/2022

Altered WEE1 activity is associated with the progression of various cancers.

What potential therapeutic applications arise from targeting WEE1 in cancer treatment? 02/11/2022

Targeting WEE1 in cancer therapy could exploit its role in cell cycle regulation to inhibit tumor growth.

How do genetic variations in WEE1 affect cell division? 10/07/2020

Genetic mutations in WEE1 can lead to uncontrolled cell division and genomic instability.

What role does WEE1 play in checkpoint regulation? 11/24/2018

WEE1 is critical in checkpoint regulation, ensuring cells do not divide with damaged DNA.

How does WEE1 interact with other cell cycle proteins? 04/08/2018

WEE1 works in conjunction with other cell cycle proteins to regulate the timing of cell division.

What is the primary role of WEE1 in cell cycle control? 06/22/2017

WEE1 is a kinase that inhibits cell cycle progression, particularly at the G2/M checkpoint.

Customer Reviews (3)

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Reviews
07/10/2019

    Dependable results. Boosts our research credibility.

    12/12/2018

      Expertise shines. Essential for our research endeavors.

      02/12/2018

        Reliable partner in experiments. Highly recommended for research.

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