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WIPI2

Official Full Name

WD repeat domain, phosphoinositide interacting 2
Overview

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of;multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein;interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller;structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed;15602573)).
Synonyms

WIPI2; WD repeat domain, phosphoinositide interacting 2; WD repeat domain phosphoinositide-interacting protein 2; ATG18B; Atg21; CGI 50; DKFZP434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WIPI49-like protein 2; WD40 repeat protein interacting wit;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	WIPI2-309HCL	Recombinant Human WIPI2 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	WIPI2-18554M	Recombinant Mouse WIPI2 Protein	Mammalian Cell	His	Inquiry
Mouse	WIPI2-10182M-B	Recombinant Mouse WIPI2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	WIPI2-10182M	Recombinant Mouse WIPI2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	WIPI2-6593R	Recombinant Rat WIPI2 Protein	Mammalian Cell	His	Inquiry
Rat	WIPI2-6249R-B	Recombinant Rat WIPI2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	WIPI2-6249R	Recombinant Rat WIPI2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	WIPI2-827Z	Recombinant Zebrafish WIPI2	Mammalian Cell	His	Inquiry
Chicken	WIPI2-1313C	Recombinant Chicken WIPI2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

WIPI2 involved in several pathways and played different roles in them. We selected most pathways WIPI2 participated on our site, such as Cellular responses to stress, Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIPI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular responses to stress	CEBPB;TERF1;TNIK;HSPA13;EED;ATG101;PRDX3;HSPH1;TXN
Macroautophagy	MAP1LC3B;AMBRA1B;WDR45;DYNLL2B;AMBRA1A;ATG7;GABARAP;ATG9A;ATG101

WIPI2 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-5-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIPI2 itself. We selected most functions WIPI2 had, and list some proteins which have the same functions with WIPI2. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol-3,5-bisphosphate binding	SNX3;RAG2;GBF1;D6WSU116E;SH3PXD2B;WIPI2;PHLDA3;WDR45L;MAPKAP1
phosphatidylinositol-3-phosphate binding	SESTD1;LANCL2;PLEKHF1;WDR45L;NCF4;BBS5;KIF16B;SNX3;SNX13
phosphatidylinositol-5-phosphate binding	LANCL2;JPH2;PHLDA3;SNX3;SNX24;SH3PXD2B;RS1;WIPI2;PLEKHF1
protein binding	BTG3;POU2F3;USP6;SEPSECS;PRMT8;ZNF581;DHX30;DPCD;PRTFDC1

WIPI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIPI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WIPI2.

ARL6IP1; RABAC1; POT1; FLNC; BTBD8; NUDC; PFKP