WRN
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Official Full Name
Werner syndrome, RecQ helicase-like
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Overview
The RecQ family of DNA and RNA helicases is a family of enzymes that has been shown to be important to genome integrity (1). Members of this family function in several DNA repair processes including double strand break repair, homologous recombination, an -
Synonyms
WRN; Werner syndrome, RecQ helicase-like; Werner syndrome; Werner syndrome ATP-dependent helicase; RECQ3; RECQL2; exonuclease WRN; recQ protein-like 2; DNA helicase, RecQ-like type 3; RECQL3; DKFZp686C2056;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- Insect Cells
- Mammalian Cell
- Sf9 insect cells
- Wheat Germ
- His
- His (Fc)
- Avi
- Myc
- MBP
- N/A
- N
- GST
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | WRN-30699TH | Recombinant Human WRN | Wheat Germ | N/A | 111 amino acids |
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| Human | WRN-1388H | Recombinant Human WRN protein, His&Myc-tagged | E.coli | His&Myc | 500-946aa |
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| Human | WRN-1389H | Recombinant Human WRN Protein(500-946aa), N-His-tagged | E.coli | His | 500-946aa |
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| Human | WRN-1387H | Recombinant Human WRN Protein(500-946aa), His&MBP-tagged | E.coli | His/MBP | 500-946aa |
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| Human | WRN-12H | Recombinant Human WRN Protein, 517-1093, N-GST tagged | Sf9 insect cells | N-GST | 517-1093 |
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| Human | WRN-1390H | Recombinant Human WRN Protein(517-1093aa), His-tagged | Insect Cells | His | 517-1093aa |
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| Human | WRN-13H | Recombinant Human WRN Protein, non-tagged, Asn500-Gln1229 | Insect Cells | N/A | Asn500-Gln1229 |
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| Mouse | WRN-18584M | Recombinant Mouse WRN Protein | Mammalian Cell | His |
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| Mouse | WRN-10206M | Recombinant Mouse WRN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | WRN-10206M-B | Recombinant Mouse WRN Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | WRN-5447C | Recombinant Chicken WRN | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- WRN Related Articles
WRN involved in several pathways and played different roles in them. We selected most pathways WRN participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with WRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double-Strand Break Repair | RHNO1;RAD17;RIF1;FUZ;PARP1;HTATIP;BABAM1;RAD50;PARP2 |
| DNA Repair | USP43;COPS4;BABAM1;RAD18;EME1;PNKP;MCRS1;DNA2;BAZ1B |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | TIPIN;BRE;KIAA0146;HUS1;TP53BP1;RAD1;PPP4CA;RNF168;FUZ |
| HDR through Homologous Recombination (HRR) | TOPBP1;RAD9;RAD51AP1;HUS1;FUZ;KIAA0146;EME2;RAD9B;RTEL1 |
| HDR through Single Strand Annealing (SSA) | RHNO1;WRN;TOPBP1 |
| Homologous DNA Pairing and Strand Exchange | RAD51AP1;TOPBP1;RHNO1;WRN |
| Homology Directed Repair | RNF4;PPP4R2;RTEL1;KIAA0146;FUZ;PPP4R2A;TIMELESS;PPP4R2B;RHNO1 |
| Integrated Pancreatic Cancer Pathway | CD82;MYT1;CST3;GPRC5A;MST1;RB1CC1;RAPGEF3;IL11;NOXA1 |
WRN has several biochemical functions, for example, 3-5 DNA helicase activity, 3-5 exonuclease activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WRN itself. We selected most functions WRN had, and list some proteins which have the same functions with WRN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 DNA helicase activity | WRN;ERCC3;CDC45;FBXO18;GINS1 |
| 3-5 exonuclease activity | RAD9B;MRE11A;EXD1;REXO2;APEX1;RAD9;POLE;APLF;POLG |
| ATP binding | VMHC;OASL;AGAP2;NAV2;RARS2;NME6;UBE2I;NMNAT3;TTLL9 |
| ATP-dependent 3-5 DNA helicase activity | WRN;RECQL4;ASCC3;BLM |
| ATP-dependent DNA helicase activity | RUVBL2;CHST13;CHD2;RTEL1;DDX11;RECQL;CHD1;BRIP1;XRCC6 |
| ATPase activity | WRNIP1;IDE;MYO9B;NSFB;ABCE1;ATF7IP;PMS1;ABCD1;ABCG3 |
| DNA binding | CHD4;ZBTB12;ZFP654;ZNF18;CTCFL;ZNF669;NKX2.4A;UBP1;MBD3A |
| DNA helicase activity | CHD8;RUVBL1;PIF1;MCM2;MCM6L;DNA2;SUPV3L1;IGHMBP2;RAD54B |
| G-quadruplex DNA binding | BLM;LONP1;DHX36;WRN |
| Y-form DNA binding | WRN;MEN1;RAD18;MSH3;MSH2 |
| bubble DNA binding | WRN;ERCC5;BLM;RECQL4;HMGB1;NEIL3 |
| exonuclease activity | ISG20;REXO1L1;CNOT6L;EXOSC9;WRN;XRN1;CNOT6;DOM3Z;RAD9 |
| four-way junction helicase activity | BLM;WRN |
| helicase activity | GTF2F2A;HLTF;DDX3;DHX34;IFIH1;DQX1;DDX6;DDX19B;MCM6L |
| magnesium ion binding | PKMA;PKMB;CIB3;NUAK2;IMPA2;FEN1;MARK1;PGM3;IDH3G |
| manganese ion binding | IMPA1;ENDOU;B4GALT7;LAP3;XPNPEP1;PCK1;GALNT2;HMGCL;PPM1N |
| protein binding | ZMYM2;DNAJC27;ACO1;MLLT4;NF1;ERN1;AGTRAP;SUMO2;GNL3 |
| protein complex binding | MAPK8IP2;KAT6B;SHARPIN;Apba1;SIX2;CDKN1A;UQCRFS1;C8A;GNB4 |
| protein homodimerization activity | SLC16A1;NR2F2;SNF8;CEBPA;NFKB1;CADM2A;PTPRE;NCR3;ACCS |
WRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WRN here. Most of them are supplied by our site. Hope this information will be useful for your research of WRN.
XRCC5; XRCC6; RPA1
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in WRN can disrupt its enzymatic activities, leading to genomic instability and disease.
Altered WRN activity is associated with accelerated aging and increased risk of age-related diseases.
WRN plays a crucial role in both DNA repair and replication processes.
Deficiency in WRN leads to accelerated aging symptoms in Werner syndrome, due to impaired DNA repair.
Therapies targeting WRN aim to enhance DNA repair mechanisms, potentially treating Werner syndrome and related conditions.
WRN cooperates with other proteins to ensure accurate DNA repair and replication.
WRN is involved in DNA repair and maintenance of genomic stability.
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