WWP1
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Official Full Name
WW domain containing E3 ubiquitin protein ligase 1
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Overview
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] -
Synonyms
WWP1; WW domain containing E3 ubiquitin protein ligase 1; AIP5; Tiul1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; atrophin-1 interacting protein 5; atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- HEK293
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | WWP1-75H | Recombinant Human WWP1, GST-tagged | Sf9 Insect Cell | GST |
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| Human | WWP1-31531TH | Recombinant Human WWP1, FLAG-tagged | Insect Cell | Flag | 921 amino acids |
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| Human | WWP1-477H | Recombinant Human WWP1, GST-tagged | Sf9 Insect Cell | Flag |
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| Human | WWP1-273HCL | Recombinant Human WWP1 293 Cell Lysate | HEK293 | N/A |
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| Rhesus Macaque | WWP1-5224R | Recombinant Rhesus monkey WWP1 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | WWP1-5037R-B | Recombinant Rhesus Macaque WWP1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | WWP1-5037R | Recombinant Rhesus Macaque WWP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Chicken | WWP1-1926C | Recombinant Chicken WWP1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
WWP1 involved in several pathways and played different roles in them. We selected most pathways WWP1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | KIF26A;NRG3;AGO2;CTSO;CD226;CD200R3;ASB14;AGO1;LRSAM1 |
| Antigen processing: Ubiquitination & | GAN;TRIM39;KLHL21;ASB11;RNF14;ASB17;MKRN1;RNF220;TRIM11 |
| Proteasome degradation | FBXO3;ASB7;RBCK1;UBE2F;ASB3;TRIM63;TRIM11;BLMH;FBXO17 |
| Class I MHC mediated antigen processing & | NPEPPS;UBE2J2;RNF182;UBR1;STUB1;ASB14;RNF111;UBA5;CTSL2 |
| presentation | UBE2J2;TRIM41;UBE2F;UBR2;CTSS;KLHL20;HUWE1;ASB10;NPEPPS |
| Downregulation of ERBB4 signaling | |
| Endocytosis | VPS37B;WIPF1;STAMBPA;HLA-B;WASLA;STAMBP;ARF3B;HLA-C;NEDD4 |
| ErbB4 signaling events | YAP1;WWOX;CBFA2T3;WWP1 |
| Immune System | Txn1;KLRG1;NLRC5;ASB4;CFHL2;MICA;POLR3F;TRIM10;TRIM29 |
| Ion channel transport | TSC22D3;SCNN1D;WNK1;TTYH2;TRPC5A;ATP1A1A.2;TRPV3;TRPM4C;UNC79 |
WWP1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP1 itself. We selected most functions WWP1 had, and list some proteins which have the same functions with WWP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | CBLC;UBE2IB;ATG3;TRIM63;COP1;DTX2;MARCH6;LIPT2;RNF34 |
| protein binding | RAI2;DYNC1LI1;TXNDC12;ELAVL1;MTAP1B;CRYGD;CBS;PSMB9;TIE1 |
| ubiquitin protein ligase activity | CDC34A;PDZRN3B;AMFR;MGRN1;UBE2U;UBE2G1A;AKTIP;RNF222;UBE2W |
| ubiquitin-protein transferase activity | SHPRH;PEX12;PARK2;RFWD3;RC3H2;FBXO30A;PAX6;ZNRF3;RNF43 |
WWP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP1.
CPSF6; SMAD3; q8wu02_human; FBXL18; TRAF4; HSP90AB1; FBXL15; PHF20L1; WASL
- Q&As
- Reviews
Q&As (6)
Ask a questionThe onset, progression, and prognosis of the disease can be assessed by examining the expression level, activity, and interaction with other proteins of the WWP1 protein. These features can also be used to develop new biomarkers and drug targets.
Some studies have shown that abnormal expression of WWP1 protein may be related to the occurrence and progression of some diseases. For example, in some cancers, the expression level of the WWP1 protein may change. In addition, the WWP1 protein may also be a drug target for the treatment of these diseases.
WWP1 protein has some correlation with other apoptotic pathways. For example, it may be interrelated with apoptotic proteases such as CASP3 to jointly regulate the apoptosis process in cells. In addition, it may be associated with other apoptotic pathways, such as the mitochondrial pathway and the death receptor pathway.
Some studies have shown that mutations or abnormal expression of the WWP1 protein may be related to some diseases, such as cancer, autoimmune diseases, etc. However, the specific association needs to be confirmed by further research.
It has certain similarities with other proteins, such as they are involved in the regulation of apoptosis. However, the structure and function of the WWP1 protein are somewhat different from other proteins.
The activity can be modulated by drugs or other small molecule compounds to treat diseases related to WWP1 protein. For example, some drugs can inhibit the activity of the WWP1 protein, thereby promoting apoptosis and clearing abnormal cells.
Customer Reviews (3)
Write a reviewThe quality of WWP1 is stable and we trust them.
Catalytic activity of WWP1 is so powerful that it can easily realize chemical reactions that would otherwise be difficult to perform, and its application prospects are very bright.
I appreciate the pursuit of product quality by the producers of WWP1, and their product is very reproducible, which makes me more confident in the experimental results.
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